ARSACS project gets grant from Italian Ministry of Health

by ARSACS | Jun 4, 2018 | Research in 2017

The Italian Ministry of Health will fund the project “Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type” presented by: Summary of the Project: “Autosomal recessive spastic-ataxia of...

Completing the first high-throughput drug screening using an ARSACS fibroblast assay – Dr. Bernard Brais and Dr. Michel Bouvier

by ARSACS | Aug 31, 2017 | Research in 2017

Project description to come   Duration : One year Grant: $100,000 Contacts: Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4 Tel:(514)-398-3334;...

Complete the characterization of Sacsin Interacome and establish how it is modified in disease and by therapeutic compounds – Dr. Bernard Brais and Dr. Eric Shoubridge

by ARSACS | Aug 31, 2017 | Research in 2017

  Project description to come     Duration: one year Grant: $100,000 Contacts: Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4...

Integrated Structural Studies Using Electron Microscopy and Cristallopraphy – Dr Kalle Gehring

by ARSACS | Aug 31, 2017 | Research in 2017

Project description to come. Duration: one year Grant: $98,350 Contact: Dr. Kalle Gehring, Professor Department of Biochemistry MCGill University Francesco Bellini Life Sciences Building, 3649 promenade Sir-William-Osler, Office: Room 469; Lab: Room 473, Montreal,...

Role of Neurofilaments in the Pathogenic Cascade of ARSACS – Dr. Heather Durham

by ARSACS | Aug 30, 2016 | Research in 2017

  Project description to come Duration: one year Grant: $100,000 Contact: Dr. Heather Durham, professor McGill University Tel:(514)-398-8509; Email: heather.durham@mcgill.ca

Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay- Dr. Paul Chapple

by ARSACS | Aug 25, 2016 | Research in 2017

The objectives of the research project are to: 1. Identify the proteostasis systems that are activated in sacsin null cells 2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells 3. Identify if there is evidence for disruption of...

Caractérisation des déficiences musculaires associées aux difficultés à la marche et aux transferts chez les patients atteints de l’ARSACS :de la cellule à la fonction- Dr Luc Hébert

by ARSACS | Aug 25, 2016 | Research in 2017

Caractériser les déficiences de force et de contrôle de mouvements volontaires et les limitations d’activité liées à la mobilité; 2) caractériser leurs interrelations; et 3) identifier les variables cliniques qui expliquent le mieux les limitations...

Characterizing and Ameliorating Axonal Transport Defects in ARSACS Mice – Dr. Thomas Schwartz

by ARSACS | Aug 24, 2016 | Research in 2017

    Project description to come   Duration: one year Grant: $74,000USD Contact: Dr. Thomas L. Schwarz, Professor, F.M. Kirby Neurobiology Center Children’s Hospital, Boston and Dept.of Neurobiology Harvard Medical School CLSB 12-130, 3 Blackfan...

Elucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS – Dr. Alanna Watt and Dr. Anne McKinney.

by ARSACS | Aug 23, 2016 | Research in 2017

The McKinney and Watt labs, which are located in close proximity in the Bellini Life Sciences Complex and who already share a mouse colony of ARSACS mice (Sacs-/-) will determine the physiological mode of action of TPS-100 a pharma and aminopyridines on Purkinje cell...

Mapping drug-Sacsin interactions and mitochondrial assemblies in ARSACS patient fibroblasts – Dr.Mohan Babu

by ARSACS | Apr 2, 2016 | Research in 2017

Aim 1- Mapping GI network of ARSACS-associated SACS target using CRISPR 1.1. Quantitative readout for scoring GIs 1.2. GI validation and benchmarking Aim 2 – Characterizing ARSACS-linked SACS pathways for function discovery Duration: one year Grant: $69,500...