{"id":12650,"date":"2021-04-14T21:14:20","date_gmt":"2021-04-14T21:14:20","guid":{"rendered":"https:\/\/clone.arsacs.com\/?page_id=12650"},"modified":"2026-09-14T17:09:25","modified_gmt":"2026-09-14T21:09:25","slug":"recherche","status":"publish","type":"page","link":"https:\/\/arsacs.com\/fr\/research\/","title":{"rendered":"Recherche"},"content":{"rendered":"
\n
\n
\n

Fondation de l\u2019 Ataxie Charlevoix-Saguenay<\/h2>\n

En 2006, la Fondation a \u00e9t\u00e9 cr\u00e9\u00e9e et a financ\u00e9 la premi\u00e8re recherche sur l\u2019ARSACS depuis l\u2019identification du g\u00e8ne en 2000. Il \u00e9tait crucial d\u2019entamer des recherches afin de d\u00e9couvrir un traitement pour ataxie r\u00e9cessive spastique autosomique de Charlevoix-Saguenay (ARSACS).<\/p>\n

Depuis sa cr\u00e9ation, la Fondation a financ\u00e9 plusieurs projets de recherche li\u00e9s \u00e0 cette maladie neurologique. La Fondation est un organisme caritatif qui fonctionne exclusivement gr\u00e2ce \u00e0 des dons priv\u00e9s et \u00e0 l'engagement de b\u00e9n\u00e9voles qui soutiennent cette cause.\u00a0<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
\"Recherche<\/span><\/div>\n<\/div>\n<\/div>\n\n
\n
\n

Objectifs de la recherche<\/h2>\n

Le principal objectif de la Fondation de l\u2019Ataxie Charlevoix-Saguenay est de d\u00e9velopper un traitement pour l\u2019ARSACS. Chaque ann\u00e9e, la Fondation finance plusieurs projets de recherche au Canada et \u00e0 l\u2019\u00e9tranger. Les efforts de la Fondation se concentrent actuellement dans trois grands domaines de recherche:<\/p>\n<\/div><\/div>\n\n

\uf0c3<\/span><\/span><\/div>

Financement de plusieurs projets de recherche avec des chercheurs experts dans ce domaine.<\/h4><\/div><\/div><\/div>\n\n
\uf0c3<\/span><\/span><\/div>

Former des partenariats avec d\u2019autres organisations et soci\u00e9t\u00e9s pharmaceutiques pour approfondir la compr\u00e9hension de cette maladie et mener des recherches ind\u00e9pendantes.<\/h4><\/div><\/div><\/div>\n\n
\uf0c3<\/span><\/span><\/div>

Faire des essais cliniques<\/h4><\/div><\/div><\/div>\n\n

Conseil consultatif scientifique<\/h2>\n

Toutes les demandes de subventions de recherche sont \u00e9valu\u00e9es par le Conseil consultatif scientifique de la Fondation de l'ataxie de Charlevoix-Saguenay selon des crit\u00e8res pr\u00e9cis.<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n

Subventions de recherche<\/h2>\n

Afin d\u2019encourager et d\u2019acc\u00e9l\u00e9rer le d\u00e9veloppement d\u2019un traitement pour l\u2019ARSACS, la Fondation accorde des subventions et des opportunit\u00e9s \u00e0 des chercheurs.<\/p>\n

Cette ann\u00e9e, l\u2019appel d\u2019offres de la Fondation de l\u2019Ataxie Charlevoix-Saguenay est conjointement soutenu par le \u201cRichardson Research Fund\u201d pour financer la recherche sur l\u2019ARSACS.<\/p>\n

Dans le cadre de cette offre de financement, la Fondation de l\u2019Ataxie Charlevoix-Saguenay en collaboration avec le \u201cRichardson Trust Fund\u201d poursuit son financement de projets pouvant atteindre jusqu\u2019\u00e0 100 000 $ CAN par projet et jusqu\u2019\u00e0 25 000 $ CAN par projet pour un financement de d\u00e9marrage (Seed Grant).<\/p>\n

Les deux types de subventions sont d\u2019une dur\u00e9e de 12 mois avec possibilit\u00e9 de renouvellement. Pour plus d\u2019information et postuler :\u00a0Pour plus d'informations et pour postuler<\/span>\u00a0:\u00a0\u00a0<\/span>Appel d'offres<\/a>\u00a0et\u00a0<\/span>Soumettre une demande<\/a>.<\/span><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

<\/div>\n
\n
\n

Projets de recherche sur l'ARSACS (description des projects en anglais seulement )<\/span>
2026-2027<\/span><\/h2>\n<\/div><\/div>\n<\/div>\n\n
\n

La Fondation tient \u00e0 exprimer sa profonde gratitude envers le Richardson Trust Fund<\/strong> ainsi qu\u2019envers la Fondation Action for ARSACS (\u00c9tats-Unis) pour leur g\u00e9n\u00e9reux soutien financier et leur pr\u00e9cieuse collaboration dans le financement conjoint de projets de recherche sur l\u2019ARSACS.\u00a0<\/p>\n<\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n

\n
\n

Investigating Ferroptosis as a Therapeutic Target in ARSACS \u2013 Dr Currais<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates ferroptosis, a form of regulated cell death associated with oxidative stress and mitochondrial dysfunction, as a potential disease mechanism and therapeutic target in ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Identifying Genetic Modifiers That May Influence ARSACS Symptoms \u2013 Dr Girard<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates genetic modifiers that may help explain differences in symptoms among people living with ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Targeting Cav2.1 to Restore Purkinje Cell Function in ARSACS \u2013 Dre Maltecca<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates whether targeting Cav2.1 calcium channels can restore normal Purkinje cell activity and improve disease-related abnormalities in ARSACS models.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Developing conditional mouse models and new approaches to treating ARSACS \u2013 Dr Strack<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive\u2026<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Unveiling the Role of Microglia in ARSACS \u2013 Dr Damiani<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates whether microglia, the immune cells of the brain, contribute directly to ARSACS progression and explores strategies to reduce harmful inflammation and protect neurons.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Exploring Oligodendrocyte Dysfunction and S100B Signaling in ARSACS \u2013 Dr Herrera<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates the role of oligodendrocyte dysfunction and S100B signaling in ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Restoring Purkinje Cell Activity Through Ion Channel and mGluR1 Modulation \u2013 Dre McKinney<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates whether modulation of a sodium channel subunit and mGluR1 can restore Purkinje cell function and slow ataxia in ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Using Prime Editing to Correct the Genetic Mutation Responsible for ARSACS \u2013 Dr Tremblay<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project explores Prime Editing as a way to directly correct the genetic mutation responsible for ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Understanding Early Synaptic and Neuroinflammatory Changes in ARSACS S \u2013 Dre Watt<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates early synaptic and neuroinflammatory changes that may contribute to Purkinje cell degeneration in ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Investigating Nuclear\u2013Cytoskeletal Alterations in ARSACS \u2013 Dre Morani et Dr Carollo<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project investigates how disruption of nuclear\u2013cytoskeletal interactions and the LINC complex may contribute to ARSACS pathogenesis.<\/p>\n<\/div>read more…<\/a><\/div><\/article>

Advancing a Nanoparticle-Based Gene Replacement Therapy for ARSACS \u2013 Drs Gentil et Durham<\/a><\/h2>

11 septembre 2026<\/span> | Recherches en cours<\/a><\/span><\/p>

This project aims to advance a nanoparticle-based gene replacement therapy designed to restore sacsin function in ARSACS.<\/p>\n<\/div>read more…<\/a><\/div><\/article><\/div>

\n\t
<\/div>\n\t
<\/div>\n<\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n
\n
\n\n<\/div>\n<\/div>\n
<\/div><\/div>\n\n
\n
\n
\n
\ue03e<\/span><\/span><\/div>

Projets ant\u00e9rieurs<\/h4><\/div><\/div><\/div>\n<\/div>\n\n
\n
\ue03e<\/span><\/span><\/div>

Partenariats<\/h4><\/div><\/div><\/div>\n<\/div>\n\n
\n
\ue03e<\/span><\/span><\/div>

Rapports de projet<\/h4><\/div><\/div><\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\ue03e<\/span><\/span><\/div>

Publications<\/h4><\/div><\/div><\/div>\n<\/div>\n\n
\n
\ue03e<\/span><\/span><\/div>

Outils de recherche<\/h4><\/div><\/div><\/div>\n<\/div>\n\n
<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Alterations in the Na+\/H+Exchanger NHE6 and Glutamate Transportersmay Influence Purkinje Cell Fate in ARSACS \u2013 Louis-Charles Masson, Atchaya S. Kanagasabai, Brenda Toscano M\u00e1rquez, Julia Tourbina-Kolomiets, Francois Charron, Alanna J. Watt, R. Anne McKinney. Research by Louis-Charles Masson and colleagues..<\/p>","protected":false},"author":6,"featured_media":26149,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-12650","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/pages\/12650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=12650"}],"version-history":[{"count":436,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/pages\/12650\/revisions"}],"predecessor-version":[{"id":27033,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/pages\/12650\/revisions\/27033"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media\/26149"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=12650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}