{"id":10758,"date":"2016-03-29T04:57:06","date_gmt":"2016-03-29T04:57:06","guid":{"rendered":"https:\/\/clone.arsacs.com\/identification-of-cellular-mechanisms-underlying-tps-100-rescue-of-motor-function-in-arsacs-mice-dr-alanna-watt-and-dr-anne-mckinney-2\/"},"modified":"2026-03-16T18:08:03","modified_gmt":"2026-03-16T22:08:03","slug":"identification-of-cellular-mechanisms-underlying-tps-100-rescue-of-motor-function-in-arsacs-mice-dr-alanna-watt-and-dr-anne-mckinney-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/identification-of-cellular-mechanisms-underlying-tps-100-rescue-of-motor-function-in-arsacs-mice-dr-alanna-watt-and-dr-anne-mckinney-2\/","title":{"rendered":"&#8220;Identification of cellular mechanisms underlying TPS-100 rescue of motor function in ARSACS mice&#8221; &#8211; Dr. Alanna Watt and Dr. Anne McKinney."},"content":{"rendered":"The McKinney and Watt labs, which are located in close proximity in the Bellini Life Sciences Complex and who already share a mouse colony of ARSACS mice (Sacs-\/-) will determine the physiological mode of action of TPS-100 a pharma and aminopyridines on Purkinje cell function, including synaptic input and output. They will work closely together, to elucidate the mechanism of action of TPS-100, which has been shown to rescue motor function in ARSACS mice (personal communication,B. Brais), or similar other therapeutic agents. This work will advance the goal of a therapeutic intervention for ARSACS.\n\nDuration: two years\nGrant: $140,000 per year\nContacts:\n\n<div id=\"attachment_132\" style=\"width: 160px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-132\" class=\"size-thumbnail wp-image-132\" src=\"https:\/\/arsacs.com\/wordpress\/wp-content\/uploads\/2016\/03\/watt-1-150x150.jpg\" alt=\"Dr. Alanna Watt\" width=\"150\" height=\"150\" \/><p id=\"caption-attachment-132\" class=\"wp-caption-text\">Dr. Alanna Watt<\/p><\/div>\n\nDr. Alanna Watt, Department of Biology McGill University Bellini Life Sciences Bldg.\n3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1 Office: Rm. 265 | Lab: Rm. 257\nTel: (514)-398-2806; Fax: (514)-398-5069; Email: <a href=\"mailto:alanna.watt@mcgill.ca\">alanna.watt@mcgill.ca<\/a>\n\n<div id=\"attachment_186\" style=\"width: 160px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-186\" class=\"size-thumbnail wp-image-186\" src=\"https:\/\/arsacs.com\/wordpress\/wp-content\/uploads\/2016\/03\/Anne-McKinney-150x150.jpg\" alt=\"Anne McKinney\" width=\"150\" height=\"150\" \/><p id=\"caption-attachment-186\" class=\"wp-caption-text\">Anne McKinney<\/p><\/div>\n\nDr. Anne McKinney, Department of Pharmacology and Therapeutics,\nMcGill University Bellini Life Sciences Bldg\n3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1\nTel: (514)-398-5685; Fax: (514)-398-2045; Email: <a href=\"mailto:anne.mckinney@mcgill.ca\">anne.mckinney@mcgill.ca<\/a>","protected":false},"excerpt":{"rendered":"<p>The McKinney and Watt labs, which are located in close proximity in the Bellini Life Sciences Complex and who already share a mouse colony of ARSACS mice (Sacs-\/-) will determine the physiological mode of action of TPS-100 a pharma and aminopyridines on Purkinje cell function, including synaptic input and output. They will work closely together, [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-10758","post","type-post","status-publish","format-standard","hentry","category-22"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=10758"}],"version-history":[{"count":1,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10758\/revisions"}],"predecessor-version":[{"id":24188,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10758\/revisions\/24188"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=10758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=10758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=10758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}