{"id":10761,"date":"2016-03-28T20:58:51","date_gmt":"2016-03-28T20:58:51","guid":{"rendered":"https:\/\/clone.arsacs.com\/role-of-neurofilaments-and-mitochondria-in-the-pathogenic-cascade-of-arsacs-relevant-biomarkers-for-therapeutic-development-dr-heather-durham\/"},"modified":"2026-03-16T18:08:02","modified_gmt":"2026-03-16T22:08:02","slug":"role-of-neurofilaments-and-mitochondria-in-the-pathogenic-cascade-of-arsacs-relevant-biomarkers-for-therapeutic-development-dr-heather-durham-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/role-of-neurofilaments-and-mitochondria-in-the-pathogenic-cascade-of-arsacs-relevant-biomarkers-for-therapeutic-development-dr-heather-durham-2\/","title":{"rendered":"Role of Neurofilaments and Mitochondria in the Pathogenic Cascade of ARSACS : Relevant Biomarkers for Therapeutic Development&#8221; &#8211; Dr. Heather Durham"},"content":{"rendered":"The research project has two specific aims: to continue experiments to determine if loss of sacsin functions in NF metabolism plays a central role in pathogenesis of ARSACS and to determine the effect of sacsin domains on the phenotype in our ARSACS culture models and based on those data to develop a therapeutic peptide to move forward in preclinical testing.\n\nDuration: one year\nGrant: $100,000\nContact:\n\n<div id=\"attachment_189\" style=\"width: 160px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-189\" class=\"size-thumbnail wp-image-189\" src=\"https:\/\/arsacs.com\/wordpress\/wp-content\/uploads\/2016\/03\/heather-durham-150x150.jpg\" alt=\"Dr Heather Durham\" width=\"150\" height=\"150\" \/><p id=\"caption-attachment-189\" class=\"wp-caption-text\">Dr Heather Durham<\/p><\/div>\n\nDr. Heather Durham, professor McGill University\nTel:(514)-398-8509; Email: <a href=\"mailto:heather.durham@mcgill.ca\">heather.durham@mcgill.ca<\/a>","protected":false},"excerpt":{"rendered":"<p>The research project has two specific aims: to continue experiments to determine if loss of sacsin functions in NF metabolism plays a central role in pathogenesis of ARSACS and to determine the effect of sacsin domains on the phenotype in our ARSACS culture models and based on those data to develop a therapeutic peptide to [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-10761","post","type-post","status-publish","format-standard","hentry","category-22"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=10761"}],"version-history":[{"count":1,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10761\/revisions"}],"predecessor-version":[{"id":24185,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10761\/revisions\/24185"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=10761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=10761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=10761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}