{"id":10767,"date":"2016-04-02T14:01:51","date_gmt":"2016-04-02T14:01:51","guid":{"rendered":"https:\/\/clone.arsacs.com\/analyzing-the-influence-of-arsacs-mutations-on-the-function-of-human-neurons-derived-from-induced-pluripotent-stem-cells-dr-peter-mcpherson-and-dr-edward-fon\/"},"modified":"2026-03-16T18:08:07","modified_gmt":"2026-03-16T22:08:07","slug":"analyzing-the-influence-of-arsacs-mutations-on-the-function-of-human-neurons-derived-from-induced-pluripotent-stem-cells-dr-peter-mcpherson-and-dr-edward-fon-3","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/analyzing-the-influence-of-arsacs-mutations-on-the-function-of-human-neurons-derived-from-induced-pluripotent-stem-cells-dr-peter-mcpherson-and-dr-edward-fon-3\/","title":{"rendered":"&#8220;Analyzing the influence of ARSACS mutations on the function of human neurons derived from induced pluripotent stem cells.&#8221; \u2013 Dr. Peter McPherson and Dr. Edward Fon"},"content":{"rendered":"The researchers will use genome editing of hiPSCs to test the hypothesis that point mutations in the SACS gene lead to alterations in mitochondrial function and neurofilament organization in neurons derived from ARSACS patients.\nSpecific aim 1: Generate genome-edited neurons from fibroblasts of ARSACS patients.\nSpecific aim 2: Examine the influence of sacsin mutations on the cell biological properties of human neurons.\n\nDuration: two years\nGrant: $100,000 per year\nContacts:\n\n<div id=\"attachment_106\" style=\"width: 160px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-106\" class=\"size-thumbnail wp-image-106\" src=\"https:\/\/arsacs.com\/wordpress\/wp-content\/uploads\/2016\/03\/mcpherson-150x150.jpg\" alt=\"Dr Peter Mc Pherson\" width=\"150\" height=\"150\" \/><p id=\"caption-attachment-106\" class=\"wp-caption-text\">Dr Peter Mc Pherson<\/p><\/div>\n\nDr. Peter McPherson, Associate Professor, Montreal Neurological Institute McGill Institute\nTel:(514)-398-7355; Email: <a href=\"mailto:peter.mcpherson@mcgill.ca\">peter.mcpherson@mcgill.ca<\/a>\n\n<div id=\"attachment_213\" style=\"width: 160px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-213\" class=\"size-thumbnail wp-image-213\" src=\"https:\/\/arsacs.com\/wordpress\/wp-content\/uploads\/2016\/04\/Dr-Fon-150x150.jpg\" alt=\"Dr. Edward Fon\" width=\"150\" height=\"150\" \/><p id=\"caption-attachment-213\" class=\"wp-caption-text\">Dr. Edward Fon<\/p><\/div>\n\nDr. Edward Fon,Professor, Director McGill Parkinson Program\nMontreal Neurological Institute, McGill Institute\nTel:(514)-398-8398; Email: <a href=\"mailto:ted.fon@mcgill.ca\">ted.fon@mcgill.ca<\/a>","protected":false},"excerpt":{"rendered":"<p>The researchers will use genome editing of hiPSCs to test the hypothesis that point mutations in the SACS gene lead to alterations in mitochondrial function and neurofilament organization in neurons derived from ARSACS patients. Specific aim 1: Generate genome-edited neurons from fibroblasts of ARSACS patients. Specific aim 2: Examine the influence of sacsin mutations on [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-10767","post","type-post","status-publish","format-standard","hentry","category-22"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=10767"}],"version-history":[{"count":1,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10767\/revisions"}],"predecessor-version":[{"id":24195,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10767\/revisions\/24195"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=10767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=10767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=10767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}