{"id":10933,"date":"2016-08-25T22:47:32","date_gmt":"2016-08-25T22:47:32","guid":{"rendered":"https:\/\/clone.arsacs.com\/the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani\/"},"modified":"2026-03-16T18:08:33","modified_gmt":"2026-03-16T22:08:33","slug":"the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani-2\/","title":{"rendered":"&#8220;The Role of Sacsin in Autophagy Offers Novel Therapeutic Opportunities&#8221;- Dr. Federica Morani"},"content":{"rendered":"&nbsp;\n\nThe specific aims of the research project are the following:\nTo investigate the role of sacsin in autophagy we will propose to answer the following questions:\n1. Is autophagy defective in sacsin KD (knockdown) cells, such as SH-SY5Y or ARSACS skin fibroblasts? If yes, where is the stop in the autophagy process and how the autophagy flux operates?\n2. Are CASA and mitophagy independent or co-dependent functional pathways in ARSACS? What are the\n\n<div id=\"attachment_1734\" style=\"width: 235px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1734\" class=\"size-medium wp-image-1734\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Morani_Federica-225x300-2.jpg\" alt=\"Dr. Federica Morani\" width=\"225\" height=\"300\" \/><p id=\"caption-attachment-1734\" class=\"wp-caption-text\">Dr. Federica Morani<\/p><\/div>\n\nautophagy-related interactors of sacsin?\n3. Can pharmacological or genetic induction\/up-regulation of autophagy in sacsin KD cells\/ skin fibroblasts from ARSACS patients rescue ARSACS phenotype (in terms of cell death\/PC degeneration, mitochondrial dysfunction)?\nExperimental\n\nDuration: one year\nGrant: $55,000\nContact:\n\nDr. Federica Morani, PhD, Neurogenetics and Molecular Medicine Laboratory, IRCCS Fondazione Stella Maris\n\nVia dei Giacinti 2, 56128 Calambrone (PISA), Italy\n\nTel: (39)050-886238; Fax:(39)50-88247\n\nEmail: <a href=\"mailto:morani.federica@gmail.com\"> morani.federica@gmail.com<\/a>","protected":false},"excerpt":{"rendered":"<p>&nbsp; The specific aims of the research project are the following: To investigate the role of sacsin in autophagy we will propose to answer the following questions: 1. Is autophagy defective in sacsin KD (knockdown) cells, such as SH-SY5Y or ARSACS skin fibroblasts? If yes, where is the stop in the autophagy process and how [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":9522,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-10933","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-archives"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10933","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=10933"}],"version-history":[{"count":1,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10933\/revisions"}],"predecessor-version":[{"id":24246,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/10933\/revisions\/24246"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media\/9522"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=10933"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=10933"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=10933"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}