{"id":11146,"date":"2018-07-27T21:48:45","date_gmt":"2018-07-27T21:48:45","guid":{"rendered":"https:\/\/clone.arsacs.com\/unravelling-co-translational-quality-control-of-mutant-sacsin-in-the-arsacs-pathogenesis-dr-francesca-maltecca\/"},"modified":"2026-03-16T18:10:05","modified_gmt":"2026-03-16T22:10:05","slug":"unravelling-co-translational-quality-control-of-mutant-sacsin-in-the-arsacs-pathogenesis-dr-francesca-maltecca-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/unravelling-co-translational-quality-control-of-mutant-sacsin-in-the-arsacs-pathogenesis-dr-francesca-maltecca-2\/","title":{"rendered":"Unravelling Co-Translational Quality Control of Mutant Sacsin in the ARSACS Pathogenesis &#8211; Dr. Francesca Maltecca"},"content":{"rendered":"The main objectives of this research project are to:\n(i) verify if a co-translational QC is the cause of sacsin absence in patients, thus uncovering the\nearliest step in ARSACS pathogenesis;\n(ii) ameliorate genotype-phenotype correlation in ARSACS by assaying residual amount of sacsin\nlevels in a panel of patient fibroblasts carrying different mutations.\nThe comprehension of the molecular mechanism underlying loss of mutant sacsin is crucial to\nimprove the knowledge on ARSACS pathogenesis.\n\nDuration: One year\nGrant : $40,000\n\nContact:\n\n<div id=\"attachment_234\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-234\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrFrancescaMaltecca-150x150-2.jpg\" alt=\"Dre Francesca Maltecca\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-234\"><p id=\"caption-attachment-234\" class=\"wp-caption-text\">Dre Francesca Maltecca<\/p><\/div>\n\nDr. Francesca Maltecca, Universita Vita-Salute San Raffaele\nVia Olgettina 60 20132 Milan, Italy\nTel:39 022643.9116; Fax: 39 022643.6352 ; Email: maltecca.francesca@hsr.it","protected":false},"excerpt":{"rendered":"<p>The main objectives of this research project are to: (i) verify if a co-translational QC is the cause of sacsin absence in patients, thus uncovering the earliest step in ARSACS pathogenesis; (ii) ameliorate genotype-phenotype correlation in ARSACS by assaying residual amount of sacsin levels in a panel of patient fibroblasts carrying different mutations. The comprehension [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-11146","post","type-post","status-publish","format-standard","hentry","category-research-2018"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11146"}],"version-history":[{"count":2,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11146\/revisions"}],"predecessor-version":[{"id":24417,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11146\/revisions\/24417"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}