{"id":11147,"date":"2018-07-27T21:51:37","date_gmt":"2018-07-27T21:51:37","guid":{"rendered":"https:\/\/clone.arsacs.com\/unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack\/"},"modified":"2026-03-16T18:10:09","modified_gmt":"2026-03-16T22:10:09","slug":"unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack-2\/","title":{"rendered":"Unbiased Sacsin Client Identification and Genetic Intervention in a Mouse Model of ARSACS- Dr. Stephen Strack"},"content":{"rendered":"This research project utilizes Sacs KO mice to answer two fundamental questions:\n1) Can we leverage recent advances in quantitative proteomics to uncover early biomarkers and perhaps drivers of ARSACS pathology in the cerebellum?\n2) Can genetic modulation of the mitochondrial fission\/fusion equilibrium counteract cerebellar symptoms and PC degeneration? Results from this research are expected to advance our understanding of ARSACS disease mechanisms and point to avenues for therapeutic intervention.\n\nDuration: one year\nGrant: $50,000\n\nContact :\n\n<div id=\"attachment_228\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-228\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrStefanStrack-150x150-2.jpg\" alt=\"Dr. Stefan Strack\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-228\"><p id=\"caption-attachment-228\" class=\"wp-caption-text\">Dr. Stefan Strack<\/p><\/div>\n\nDr.Stefan Strack, Professor of Pharmacology University of Iowa Carver College of Medicine\n2-452 BSB, 51 Newton Rd. Iowa City, IA 52242\nTel:(office\/lab): (319)384-44[39\/47]; Fax: (319) 335-8930\nwww.medicine.uiowa.edu\/pharmacology\/faculty\/strack.html","protected":false},"excerpt":{"rendered":"<p>This research project utilizes Sacs KO mice to answer two fundamental questions: 1) Can we leverage recent advances in quantitative proteomics to uncover early biomarkers and perhaps drivers of ARSACS pathology in the cerebellum? 2) Can genetic modulation of the mitochondrial fission\/fusion equilibrium counteract cerebellar symptoms and PC degeneration? Results from this research are expected [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-11147","post","type-post","status-publish","format-standard","hentry","category-research-2018"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11147"}],"version-history":[{"count":2,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11147\/revisions"}],"predecessor-version":[{"id":24425,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11147\/revisions\/24425"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}