{"id":11678,"date":"2016-08-25T22:47:32","date_gmt":"2016-08-25T22:47:32","guid":{"rendered":"https:\/\/clone.arsacs.com\/disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple\/"},"modified":"2016-08-25T22:47:32","modified_gmt":"2016-08-25T22:47:32","slug":"disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple\/","title":{"rendered":"“Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay””- Dr. Paul Chapple"},"content":{"rendered":"

1. Identify the proteostasis systems that are activated in sacsin null cells<\/p>\n

2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells<\/p>\n

3. Identify if there is evidence for disruption of proteostasis systems in human ARSACS neurons.<\/p>\n

 <\/p>\n

\"Dr.

Dr. Paul Chapple<\/p><\/div>\n

 <\/p>\n

 <\/p>\n

Duration:  Second year of a three year project
\nGrant: 18,965 Pounds ($32,400CDN) per year
\nContact:<\/p>\n

Dr.Paul Chapple, Professor of Molecular Cell Biology
\nCentre for Endocrinology Barts and The London, Queen Mary’s School of Medicine and Dentistry
\n1st Floor North ,John Vane Science Building,Charterhouse Square
\nLondon, EC1M 6BQ
\nT: +44 (0) 20 7882 6242
\nE: j.p.chapple@qmul.ac.uk<\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

1. Identify the proteostasis systems that are activated in sacsin null cells 2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells 3. Identify if there is evidence for disruption of proteostasis systems in human ARSACS neurons.       Duration:  Second year of a three year project Grant: 18,965 Pounds ($32,400CDN) […]<\/p>\n","protected":false},"author":3,"featured_media":9474,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-11678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche-2017"],"yoast_head":"\n"Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay""- Dr. Paul Chapple - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\""Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay""- Dr. Paul Chapple - ARSACS\" \/>\n<meta property=\"og:description\" content=\"1. 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