{"id":11678,"date":"2016-08-25T22:47:32","date_gmt":"2016-08-25T22:47:32","guid":{"rendered":"https:\/\/clone.arsacs.com\/disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple\/"},"modified":"2026-03-16T18:08:34","modified_gmt":"2026-03-16T22:08:34","slug":"disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/disrupted-protein-homeostasis-in-autosomal-recessive-spastic-ataxia-of-charlevoix-saguenay-dr-paul-chapple\/","title":{"rendered":"&#8220;Disrupted Protein Homeostasis in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay&#8221;&#8221;- Dr. Paul Chapple"},"content":{"rendered":"1. Identify the proteostasis systems that are activated in sacsin null cells\n\n2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells\n\n3. Identify if there is evidence for disruption of proteostasis systems in human ARSACS neurons.\n\n&nbsp;\n\n<div id=\"attachment_274\" style=\"width: 310px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-274\" class=\"size-full wp-image-274\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrPaulChapple-2.jpg\" alt=\"Dr. Paul Chapple\" width=\"300\" height=\"300\"><p id=\"caption-attachment-274\" class=\"wp-caption-text\">Dr. Paul Chapple<\/p><\/div>\n\n&nbsp;\n\n&nbsp;\n\nDuration: &nbsp;Second year of a three year project\nGrant:&nbsp;18,965 Pounds ($32,400CDN) per year\nContact:\n\nDr.Paul Chapple, Professor of Molecular Cell Biology\nCentre for Endocrinology Barts and The London, Queen Mary's School of Medicine and Dentistry\n1st Floor North ,John Vane Science Building,Charterhouse Square\nLondon, EC1M 6BQ\nT: +44 (0) 20 7882 6242\nE: <span id=\"cloak18605\"><a href=\"mailto:j.p.chapple@qmul.ac.uk\">j.p.chapple@qmul.ac.uk<\/a><\/span>\n\n&nbsp;","protected":false},"excerpt":{"rendered":"<p>1. Identify the proteostasis systems that are activated in sacsin null cells 2. Identify proteins that are recruited to the aggresome-like structure in sacsin null cells 3. Identify if there is evidence for disruption of proteostasis systems in human ARSACS neurons. &nbsp; &nbsp; &nbsp; Duration: &nbsp;Second year of a three year project Grant:&nbsp;18,965 Pounds ($32,400CDN) [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":9474,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-11678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche-2017"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11678"}],"version-history":[{"count":1,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11678\/revisions"}],"predecessor-version":[{"id":24250,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11678\/revisions\/24250"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media\/9474"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}