{"id":11679,"date":"2016-08-25T22:47:32","date_gmt":"2016-08-25T22:47:32","guid":{"rendered":"https:\/\/clone.arsacs.com\/the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani\/"},"modified":"2016-08-25T22:47:32","modified_gmt":"2016-08-25T22:47:32","slug":"the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani\/","title":{"rendered":"&#8220;The Role of Sacsin in Autophagy Offers Novel Therapeutic Opportunities&#8221;- Dr. Federica Morani"},"content":{"rendered":"<p>The specific aims of the research project are the following:<br \/>\nTo investigate the role of sacsin in autophagy we will propose to answer the following questions:<br \/>\n1. Is autophagy defective in sacsin KD (knockdown) cells, such as SH-SY5Y or ARSACS skin fibroblasts? If yes, where is the stop in the autophagy process and how the autophagy flux operates?<br \/>\n2. Are CASA and mitophagy independent or co-dependent functional pathways in ARSACS? What are the<\/p>\n<div id=\"attachment_1734\" style=\"width: 235px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1734\" class=\"size-medium wp-image-1734\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Morani_Federica-225x300-2.jpg\" alt=\"Dr. Federica Morani\" width=\"225\" height=\"300\" \/><p id=\"caption-attachment-1734\" class=\"wp-caption-text\">Dr. Federica Morani<\/p><\/div>\n<p>autophagy-related interactors of sacsin?<br \/>\n3. Can pharmacological or genetic induction\/up-regulation of autophagy in sacsin KD cells\/ skin fibroblasts from ARSACS patients rescue ARSACS phenotype (in terms of cell death\/PC degeneration, mitochondrial dysfunction)?<br \/>\nExperimental<\/p>\n<p>Duration: one year<br \/>\nGrant: $55,000<\/p>\n<p>Contact:<\/p>\n<p>Dr. Federica Morani, PhD, Neurogenetics and Molecular Medicine Laboratory, IRCCS Fondazione Stella Maris<\/p>\n<p>Via dei Giacinti 2, 56128 Calambrone (PISA), Italy<\/p>\n<p>Tel: (39)050-886238; Fax: (39)050-886247<\/p>\n<p>Email: <a href=\"mailto:morani.federica@gmail.com\"> morani.federica@gmail.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The specific aims of the research project are the following: To investigate the role of sacsin in autophagy we will propose to answer the following questions: 1. Is autophagy defective in sacsin KD (knockdown) cells, such as SH-SY5Y or ARSACS skin fibroblasts? If yes, where is the stop in the autophagy process and how the [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":9522,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[21],"tags":[],"class_list":["post-11679","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives-nouvelles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>&quot;The Role of Sacsin in Autophagy Offers Novel Therapeutic Opportunities&quot;- Dr. Federica Morani - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/the-role-of-sacsin-in-autophagy-offers-novel-therapeutic-opportunities-dr-federica-morani\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;The Role of Sacsin in Autophagy Offers Novel Therapeutic Opportunities&quot;- Dr. Federica Morani - ARSACS\" \/>\n<meta property=\"og:description\" content=\"The specific aims of the research project are the following: To investigate the role of sacsin in autophagy we will propose to answer the following questions: 1. 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