{"id":11764,"date":"2018-06-04T20:15:38","date_gmt":"2018-06-04T20:15:38","guid":{"rendered":"https:\/\/clone.arsacs.com\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\/"},"modified":"2018-06-04T20:15:38","modified_gmt":"2018-06-04T20:15:38","slug":"le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\/","title":{"rendered":"Le minist\u00e8re de la sant\u00e9 de l\u2019Italie finance un projet ARSACS ."},"content":{"rendered":"

Le minist\u00e8re de la sant\u00e9 de l\u2019Italie accorde du finacement pour le projet \u00ab Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type \u00bb pr\u00e9sent\u00e9 par:<\/p>\n

\"Dr.

Dr. Filippo M. Santorelli, Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa.<\/p><\/div>\n

\"Dr.

Dr. Francesca Maltecca, Neurogenomics Unit, Ospedale San Raffaele, Milan, Italy<\/p><\/div>\n

\"\"

Dr. Gianni Ciofani, Smart Bio-Interfaces, Istituto Italiano di Tecnologia (IIT), Pontedera (PI)<\/p><\/div>\n

R\u00e9sum\u00e9 du projet :<\/strong><\/div>\n

\u00ab Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a protein whose function is only in part understood. Mutations in SACS impair chaperone-mediated protein-folding activity and mitochondrial(mt) dynamics in Sacs knock-out (KO) mice and human ARSACS cells. Our challenge is to find tools capable to reverse sacsin defects in mice and to identify biomarkers of efficacy in clinical trials. We will use a dual approach: we will analyze mt functionality in Purkinje cells needed to fine tuning new treatment opportunities in Sacs KO mice and will seek for prognostic\/predictive biomarkers in patients in order to design new intervention strategies aimed at overcoming brain alterations. To cope with brain alterations in ARSACS and in similar neurological conditions with altered mt functionality, we will also test new nanovectors to easy drug delivery in mutant cells. \u00bb<\/p>\n","protected":false},"excerpt":{"rendered":"

Le minist\u00e8re de la sant\u00e9 de l\u2019Italie accorde du finacement pour le projet \u00ab Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type \u00bb pr\u00e9sent\u00e9 par: R\u00e9sum\u00e9 du projet : \u00ab Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[7],"tags":[],"class_list":["post-11764","post","type-post","status-publish","format-standard","hentry","category-recherche-2017"],"yoast_head":"\nLe minist\u00e8re de la sant\u00e9 de l\u2019Italie finance un projet ARSACS . - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le minist\u00e8re de la sant\u00e9 de l\u2019Italie finance un projet ARSACS . - ARSACS\" \/>\n<meta property=\"og:description\" content=\"Le minist\u00e8re de la sant\u00e9 de l\u2019Italie accorde du finacement pour le projet \u00ab Insight into new therapeutic preclinical strategies in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay type \u00bb pr\u00e9sent\u00e9 par: R\u00e9sum\u00e9 du projet : \u00ab Autosomal recessive spastic-ataxia of Charlevoix-Saguenay (ARSACS) is a multisystem hereditary ataxia associated with mutations in SACS, encoding sacsin, a […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/arsacs.com\/fr\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\/\" \/>\n<meta property=\"og:site_name\" content=\"ARSACS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=100044457429916\" \/>\n<meta property=\"article:published_time\" content=\"2018-06-04T20:15:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Filippo_Santorelli-1-150x150-2.jpg\" \/>\n<meta name=\"author\" content=\"ARSACS\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ARSACS\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\\\/\"},\"author\":{\"name\":\"ARSACS\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/person\\\/93b66d6b897bfa131622d04b767b15f1\"},\"headline\":\"Le minist\u00e8re de la sant\u00e9 de l\u2019Italie finance un projet ARSACS .\",\"datePublished\":\"2018-06-04T20:15:38+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\\\/\"},\"wordCount\":247,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/Filippo_Santorelli-1-150x150-2.jpg\",\"articleSection\":[\"Recherche 2017\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\\\/\",\"url\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/le-ministere-de-la-sante-de-litalie-finance-un-projet-arsacs\\\/\",\"name\":\"Le minist\u00e8re de la sant\u00e9 de l\u2019Italie finance un projet ARSACS . - 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