{"id":11781,"date":"2018-07-27T21:51:37","date_gmt":"2018-07-27T21:51:37","guid":{"rendered":"https:\/\/clone.arsacs.com\/unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack\/"},"modified":"2021-07-20T14:43:09","modified_gmt":"2021-07-20T18:43:09","slug":"unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack\/","title":{"rendered":"Unbiased Sacsin Client Identification and Genetic Intervention in a Mouse Model of ARSACS- Dr. Stephen Strack"},"content":{"rendered":"<p>This research project utilizes Sacs KO mice to answer two fundamental questions:<br \/>\n1) Can we leverage recent advances in quantitative proteomics to uncover early biomarkers and perhaps drivers of ARSACS pathology in the cerebellum?<br \/>\n2) Can genetic modulation of the mitochondrial fission\/fusion equilibrium counteract cerebellar symptoms and PC degeneration? Results from this research are expected to advance our understanding of ARSACS disease mechanisms and point to avenues for therapeutic intervention.<\/p>\n<p>Duration: one year<br \/>\nGrant: $50,000<\/p>\n<p>Contact :<\/p>\n<div id=\"attachment_228\" style=\"width: 160px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-228\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrStefanStrack-150x150-2.jpg\" alt=\"Dr. Stefan Strack\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-228\"><p id=\"caption-attachment-228\" class=\"wp-caption-text\">Dr. Stefan Strack<\/p><\/div>\n<p>Dr.Stefan Strack, Professor of Pharmacology University of Iowa Carver College of Medicine<br \/>\n2-452 BSB, 51 Newton Rd. Iowa City, IA 52242<br \/>\nTel:(office\/lab): (319)384-44[39\/47]; Fax: (319) 335-8930<br \/>\nwww.medicine.uiowa.edu\/pharmacology\/faculty\/strack.html<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This research project utilizes Sacs KO mice to answer two fundamental questions: 1) Can we leverage recent advances in quantitative proteomics to uncover early biomarkers and perhaps drivers of ARSACS pathology in the cerebellum? 2) Can genetic modulation of the mitochondrial fission\/fusion equilibrium counteract cerebellar symptoms and PC degeneration? Results from this research are expected [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-11781","post","type-post","status-publish","format-standard","hentry","category-recherche-2018"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Unbiased Sacsin Client Identification and Genetic Intervention in a Mouse Model of ARSACS- Dr. Stephen Strack - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/unbiased-sacsin-client-identification-and-genetic-intervention-in-a-mouse-model-of-arsacs-dr-stephen-strack\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unbiased Sacsin Client Identification and Genetic Intervention in a Mouse Model of ARSACS- Dr. Stephen Strack - ARSACS\" \/>\n<meta property=\"og:description\" content=\"This research project utilizes Sacs KO mice to answer two fundamental questions: 1) Can we leverage recent advances in quantitative proteomics to uncover early biomarkers and perhaps drivers of ARSACS pathology in the cerebellum? 2) Can genetic modulation of the mitochondrial fission\/fusion equilibrium counteract cerebellar symptoms and PC degeneration? 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