{"id":11787,"date":"2018-07-27T21:45:37","date_gmt":"2018-07-27T21:45:37","guid":{"rendered":"https:\/\/clone.arsacs.com\/axonal-transport-and-axonal-survival-in-arsacs-mice-dr-thomas-schwarz\/"},"modified":"2021-07-20T14:43:09","modified_gmt":"2021-07-20T18:43:09","slug":"axonal-transport-and-axonal-survival-in-arsacs-mice-dr-thomas-schwarz","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/axonal-transport-and-axonal-survival-in-arsacs-mice-dr-thomas-schwarz\/","title":{"rendered":"Axonal Transport and Axonal Survival in ARSACS Mice- Dr. Thomas Schwarz"},"content":{"rendered":"

The goal of this project is to develop therapeutic interventions that would ameliorate the
\ndegeneration of neurons in ARSACS.
\nSpecific Aims.
\n1. Test compounds that enhance mitochondrial motility in rat hippocampal neurons to determine if they also
\nenhance motility in sacsin -\/- mouse neurons.
\n2. Establish conditions for cultured sacsin-\/- neurons that will provoke the formation of neurofilament
\naggregates seen in vivo in older sacsin -\/- mice and determine if those aggregates impeded proper
\ntransport of mitochondria.
\n3. Test compounds that enhance mitochondrial motility to determine if they can restore normal levels of
\nmitochondrial transport in the presence of neurofilament aggregates.
\n4. Determine if the NMNAT\/SARM pathway is involved in the degeneration and death of neurons in vivo in
\nsacsin -\/- mice.<\/p>\n

Duration: one year
\nGrant: $50,000
\nContact:<\/p>\n

\"Dr.

Dr. Thomas L. Schwarz<\/p><\/div>\n

Dr. Thomas L. Schwarz, Professor, F.M. Kirby Neurobiology Center Children\u2019s Hospital, Boston Children’s Hospital CLSB12-130
\nHarvard Medical School CLSB 12-130, 3 Blackfan Street, Boston, MA 02115
\nTel:(617)-919-2219 (office) or (717)-919-2271(fax)<\/p>\n","protected":false},"excerpt":{"rendered":"

The goal of this project is to develop therapeutic interventions that would ameliorate the degeneration of neurons in ARSACS. Specific Aims. 1. Test compounds that enhance mitochondrial motility in rat hippocampal neurons to determine if they also enhance motility in sacsin -\/- mouse neurons. 2. 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