{"id":11990,"date":"2020-10-30T14:13:34","date_gmt":"2020-10-30T14:13:34","guid":{"rendered":"https:\/\/clone.arsacs.com\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/"},"modified":"2021-10-29T16:20:48","modified_gmt":"2021-10-29T20:20:48","slug":"therapeutic-approaches-for-arsacs-dr-benoit-gentil-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/","title":{"rendered":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil"},"content":{"rendered":"<p>ARSACS is characterised by the lack of sacsin expression and the formation of intermediate filaments bundles in neurons and fibroblasts derived from skin biopsies. Our strategy over the last years has been aimed at developing a replacement therapy, by peptide and\/or gene vectors and, because of the chaperone function of sacsin, to investigate the potential of alternative therapies already in development in our laboratory to promote protein chaperoning. We have defined minimal domains necessary for the replacement therapy and identified that HDAC inhibitors have a strong therapeutic potential. For the next year, we will pursue our efforts.<\/p>\n<p>AIM 1. Development of peptide and gene therapies. We have generated a AAV9 carrying a combination of sacsin domains and generated peptides derived from sacsin domains. We will test the efficacy of this vector in resorbing intermediate filament bundles in neurons.<\/p>\n<p>AIM 2. Assessment of therapeutic potential of brain permeant HDAC inhibitors for ARSACS. We will examine the role of different HDACs inhibitors in resorbing intermediate filaments bundles in culture.<\/p>\n<p>Grant: $100,000<\/p>\n<p>Contact:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-6218\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg\" alt=\"\" width=\"150\" height=\"150\">Dr. Benoit Gentil, Department of Kinesiology and Physical Education, McGill University<br \/>\n475 Pine Avenue West, room 210, Montreal, Quebec&nbsp; H3A 2B4<\/p>\n<p>Tel: 514-398-4184 ext 00102&nbsp; email:benoit.gentil@mcgill.ca<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ARSACS is characterised by the lack of sacsin expression and the formation of intermediate filaments bundles in neurons and fibroblasts derived from skin biopsies. Our strategy over the last years has been aimed at developing a replacement therapy, by peptide and\/or gene vectors and, because of the chaperone function of sacsin, to investigate the potential [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[81],"tags":[],"class_list":["post-11990","post","type-post","status-publish","format-standard","hentry","category-recherche-2020"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil - ARSACS\" \/>\n<meta property=\"og:description\" content=\"ARSACS is characterised by the lack of sacsin expression and the formation of intermediate filaments bundles in neurons and fibroblasts derived from skin biopsies. Our strategy over the last years has been aimed at developing a replacement therapy, by peptide and\/or gene vectors and, because of the chaperone function of sacsin, to investigate the potential [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/\" \/>\n<meta property=\"og:site_name\" content=\"ARSACS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=100044457429916\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-30T14:13:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-29T20:20:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg\" \/>\n<meta name=\"author\" content=\"ARSACS\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ARSACS\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/\"},\"author\":{\"name\":\"ARSACS\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/person\\\/93b66d6b897bfa131622d04b767b15f1\"},\"headline\":\"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil\",\"datePublished\":\"2020-10-30T14:13:34+00:00\",\"dateModified\":\"2021-10-29T20:20:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/\"},\"wordCount\":207,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/benoitgentil-150x150-1.jpg\",\"articleSection\":[\"Recherche 2020\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/\",\"url\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/\",\"name\":\"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil - ARSACS\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/benoitgentil-150x150-1.jpg\",\"datePublished\":\"2020-10-30T14:13:34+00:00\",\"dateModified\":\"2021-10-29T20:20:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#primaryimage\",\"url\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/benoitgentil-150x150-1.jpg\",\"contentUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/benoitgentil-150x150-1.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/arsacs.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#website\",\"url\":\"https:\\\/\\\/arsacs.com\\\/\",\"name\":\"Fondation de l'Ataxie Charlevoix-Saguenay\",\"description\":\"Research That Heals\",\"publisher\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/arsacs.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#organization\",\"name\":\"ARSACS\",\"url\":\"https:\\\/\\\/arsacs.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/06\\\/logo_ARSACS_fr_flat.png\",\"contentUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/06\\\/logo_ARSACS_fr_flat.png\",\"width\":291,\"height\":84,\"caption\":\"ARSACS\"},\"image\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/profile.php?id=100044457429916\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/person\\\/93b66d6b897bfa131622d04b767b15f1\",\"name\":\"ARSACS\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e3b226aca332e58d41ec45fa04620bcbd869d2e4e661cacde31eeb3ae6a5708d?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e3b226aca332e58d41ec45fa04620bcbd869d2e4e661cacde31eeb3ae6a5708d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/e3b226aca332e58d41ec45fa04620bcbd869d2e4e661cacde31eeb3ae6a5708d?s=96&d=mm&r=g\",\"caption\":\"ARSACS\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil - ARSACS","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/","og_locale":"fr_FR","og_type":"article","og_title":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil - ARSACS","og_description":"ARSACS is characterised by the lack of sacsin expression and the formation of intermediate filaments bundles in neurons and fibroblasts derived from skin biopsies. Our strategy over the last years has been aimed at developing a replacement therapy, by peptide and\/or gene vectors and, because of the chaperone function of sacsin, to investigate the potential [&hellip;]","og_url":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/","og_site_name":"ARSACS","article_publisher":"https:\/\/www.facebook.com\/profile.php?id=100044457429916","article_published_time":"2020-10-30T14:13:34+00:00","article_modified_time":"2021-10-29T20:20:48+00:00","og_image":[{"url":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg","type":"","width":"","height":""}],"author":"ARSACS","twitter_card":"summary_large_image","twitter_misc":{"Written by":"ARSACS","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#article","isPartOf":{"@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/"},"author":{"name":"ARSACS","@id":"https:\/\/arsacs.com\/#\/schema\/person\/93b66d6b897bfa131622d04b767b15f1"},"headline":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil","datePublished":"2020-10-30T14:13:34+00:00","dateModified":"2021-10-29T20:20:48+00:00","mainEntityOfPage":{"@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/"},"wordCount":207,"commentCount":0,"publisher":{"@id":"https:\/\/arsacs.com\/#organization"},"image":{"@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#primaryimage"},"thumbnailUrl":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg","articleSection":["Recherche 2020"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/","url":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/","name":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil - ARSACS","isPartOf":{"@id":"https:\/\/arsacs.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#primaryimage"},"image":{"@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#primaryimage"},"thumbnailUrl":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg","datePublished":"2020-10-30T14:13:34+00:00","dateModified":"2021-10-29T20:20:48+00:00","breadcrumb":{"@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#primaryimage","url":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg","contentUrl":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/benoitgentil-150x150-1.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/arsacs.com\/"},{"@type":"ListItem","position":2,"name":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr. Benoit Gentil"}]},{"@type":"WebSite","@id":"https:\/\/arsacs.com\/#website","url":"https:\/\/arsacs.com\/","name":"Fondation de l'Ataxie Charlevoix-Saguenay","description":"Research That Heals","publisher":{"@id":"https:\/\/arsacs.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/arsacs.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/arsacs.com\/#organization","name":"ARSACS","url":"https:\/\/arsacs.com\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/arsacs.com\/#\/schema\/logo\/image\/","url":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/06\/logo_ARSACS_fr_flat.png","contentUrl":"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/06\/logo_ARSACS_fr_flat.png","width":291,"height":84,"caption":"ARSACS"},"image":{"@id":"https:\/\/arsacs.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/profile.php?id=100044457429916"]},{"@type":"Person","@id":"https:\/\/arsacs.com\/#\/schema\/person\/93b66d6b897bfa131622d04b767b15f1","name":"ARSACS","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/e3b226aca332e58d41ec45fa04620bcbd869d2e4e661cacde31eeb3ae6a5708d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/e3b226aca332e58d41ec45fa04620bcbd869d2e4e661cacde31eeb3ae6a5708d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e3b226aca332e58d41ec45fa04620bcbd869d2e4e661cacde31eeb3ae6a5708d?s=96&d=mm&r=g","caption":"ARSACS"}}]}},"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11990","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=11990"}],"version-history":[{"count":2,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11990\/revisions"}],"predecessor-version":[{"id":15866,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/11990\/revisions\/15866"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=11990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=11990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=11990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}