{"id":15566,"date":"2021-10-29T15:42:14","date_gmt":"2021-10-29T19:42:14","guid":{"rendered":"https:\/\/arsacs.com\/?p=15566"},"modified":"2026-03-16T18:13:33","modified_gmt":"2026-03-16T22:13:33","slug":"structural-determination-and-super-resolution-imaging-of-sacsin-dr-walid-houry-3","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/structural-determination-and-super-resolution-imaging-of-sacsin-dr-walid-houry-3\/","title":{"rendered":"\u201cStructural Determination and Super Resolution Imaging of Sacsin\u201d &#8211; Dr. Walid Houry"},"content":{"rendered":"<p>The SACS protein, whose mutation results in ARSACS, is among the largest proteins in human cells (4579 residues), which hindered the determination of its structure and made basic biochemical experiments problematic. In the proposed project, we aim to use novel tagging approaches to allow SACS purification in its native state for structural determination, and also for its super-resolution localization in fixed and live cells.<\/p>\n<p>Grant: $80,000<\/p>\n<p>Dur\u00e9e : un an<\/p>\n<p>Contact :<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-6572\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Walid_Houry_University_Toronto-e1606423339816.jpg\" alt=\"\" width=\"127\" height=\"150\">Dr. Walid A. Houry, Department of Biochemistry<\/p>\n<p>Facult\u00e9 de m\u00e9decine Temerty de l'Universit\u00e9 de Toronto<br>661 University Avenue,MaRS Centre, West Tower, Room 1612<\/p>\n<p>Toronto, ON, Canada M5G 1M1<\/p>\n<p>email: walid.houry@utoronto.ca<\/p>\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The SACS protein, whose mutation results in ARSACS, is among the largest proteins in human cells (4579 residues), which hindered the determination of its structure and made basic biochemical experiments problematic. In the proposed project, we aim to use novel tagging approaches to allow SACS purification in its native state for structural determination, and also [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[83],"tags":[],"class_list":["post-15566","post","type-post","status-publish","format-standard","hentry","category-research-in-2021"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=15566"}],"version-history":[{"count":7,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15566\/revisions"}],"predecessor-version":[{"id":24748,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15566\/revisions\/24748"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=15566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=15566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=15566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}