{"id":15574,"date":"2021-10-29T15:43:06","date_gmt":"2021-10-29T19:43:06","guid":{"rendered":"https:\/\/arsacs.com\/?p=15574"},"modified":"2026-03-16T18:13:34","modified_gmt":"2026-03-16T22:13:34","slug":"unravelling-defective-purkinje-cell-postsynaptic-signalling-in-arsacs-dr-francesca-maltecca-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/unravelling-defective-purkinje-cell-postsynaptic-signalling-in-arsacs-dr-francesca-maltecca-2\/","title":{"rendered":"\u201cUnravelling defective Purkinje cell-postsynaptic signalling in ARSACS\u201d &#8211; Dr. Francesca Maltecca"},"content":{"rendered":"<p class=\"PANormalLevelIA\" style=\"text-align: justify;\"><span lang=\"EN-US\">We discovered that sacsin specifically localizes at the post-synaptic density of the cerebellum, where it controls key proteins involved in synapse organization and trans-synaptic signaling, required for tuning the firing properties of Purkinje cells. The project aims at defining how defects in this pathway can influence Purkinje cell-spine functionality and firing, contributing to the motor coordination defects observed in ARSACS. This study may identify new valuable targets for therapeutic intervention.<\/span><\/p>\n<p>Grant: $80,000<\/p>\n<p>Dur\u00e9e : un an<\/p>\n<p>Contact :<\/p>\n<p style=\"text-align: left;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11103 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrFrancescaMaltecca-150x150-2.jpg\" alt=\"\" width=\"150\" height=\"150\"><\/p>\n<p>Dre Francesca Maltecca<\/p>\n<p>Ospedale San Raffaele<\/p>\n<p>Via Olgettina 58,20132, Milan, Italy&nbsp;&nbsp;<\/p>\n<p>email: maltecca.francesca@hsr.it<\/p>\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>We discovered that sacsin specifically localizes at the post-synaptic density of the cerebellum, where it controls key proteins involved in synapse organization and trans-synaptic signaling, required for tuning the firing properties of Purkinje cells. The project aims at defining how defects in this pathway can influence Purkinje cell-spine functionality and firing, contributing to the motor [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[83],"tags":[],"class_list":["post-15574","post","type-post","status-publish","format-standard","hentry","category-research-in-2021"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=15574"}],"version-history":[{"count":6,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15574\/revisions"}],"predecessor-version":[{"id":24749,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15574\/revisions\/24749"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=15574"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=15574"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=15574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}