{"id":15819,"date":"2021-10-29T15:36:58","date_gmt":"2021-10-29T19:36:58","guid":{"rendered":"https:\/\/arsacs.com\/?p=15819"},"modified":"2026-03-16T18:13:31","modified_gmt":"2026-03-16T22:13:31","slug":"is-arsacs-a-tauopathy-dr-paul-chapple-3-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/is-arsacs-a-tauopathy-dr-paul-chapple-3-2\/","title":{"rendered":"&#8220;Is ARSACS a Tauopathy?&#8221;- Dr. Paul Chapple"},"content":{"rendered":"<p class=\"wp-block-paragraph\">This is the continuation of the project. More specific details to come.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As an indication of the research, following is the description of last year work.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Currently we are looking carefully at sacsin\u2019s interaction with cytoskeletal proteins and defining the molecular mechanisms by which sacsin\u2019s loss disrupts cytoskeletal function. This includes research examining a link between cytoskeletal disruption, caused by loss of sacsin, and impaired formation of structures called focal adhesions that are important for cell movement. We are also looking at links between ARSACS and other neuronal diseases where cytoskeletal dysfunction is a feature, including Alzheimer\u2019s disease. One of the key challenges that we wish to solve is understanding how all of the different problems identified in cells that do not have sacsin are integrated together. If we fully understand the \u2018hierarch of events\u2019 in the molecular pathology of cells that lack sacsin it will potentially facilitate the development of treatments for ARSACS.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Duration:  3rd year of a 3 year project <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Grant: $56,906<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Contact : <\/p>\n\n\n\n<figure class=\"wp-block-image alignleft\"><img decoding=\"async\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrPaulChapple.jpg\" alt=\"Dr. Paul Chapple\" class=\"wp-image-274\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr.Paul Chapple, Professor of Molecular Cell Biology<br>Centre for Endocrinology Barts and The London, Queen Mary\u2019s School of Medicine and Dentistry <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1st Floor North , John Vane Science Building, <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Charterhouse Square, London, EC1M 6BQ<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">email:&nbsp;<a href=\"mailto:j.p.chapple@qmul.ac.uk\">j.p.chapple@qmul.ac.uk<\/a><\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\"> <\/p>","protected":false},"excerpt":{"rendered":"<p>This is the continuation of the project. More specific details to come.&nbsp;&nbsp; As an indication of the research, following is the description of last year work.&nbsp; Currently we are looking carefully at sacsin\u2019s interaction with cytoskeletal proteins and defining the molecular mechanisms by which sacsin\u2019s loss disrupts cytoskeletal function. This includes research examining a link [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[83],"tags":[],"class_list":["post-15819","post","type-post","status-publish","format-standard","hentry","category-research-in-2021"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=15819"}],"version-history":[{"count":9,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15819\/revisions"}],"predecessor-version":[{"id":24745,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/15819\/revisions\/24745"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=15819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=15819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=15819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}