{"id":17783,"date":"2022-10-25T17:21:44","date_gmt":"2022-10-25T21:21:44","guid":{"rendered":"https:\/\/arsacs.com\/?p=17783"},"modified":"2023-10-09T11:24:57","modified_gmt":"2023-10-09T15:24:57","slug":"targeting-transmembrane-ion-balance-to-restore-purkinje-cell-functionality-in-arsacs-dr-francesca-maltecca","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/targeting-transmembrane-ion-balance-to-restore-purkinje-cell-functionality-in-arsacs-dr-francesca-maltecca\/","title":{"rendered":"\u201cTargeting transmembrane ion balance to restore Purkinje cell functionality in ARSACS\u201d &#8211; Dr. Francesca Maltecca"},"content":{"rendered":"<p class=\"PANormalLevelIA\" style=\"text-align: justify;\"><span lang=\"EN-US\">We identified in murine Purkinje cells a specific interaction of sacsin with proteins regulating transmembrane ion balance, which are required for tuning the firing properties of these neurons. Our functional studies support a deregulation of ion conductance in <em>Sacs<sup>-\/-<\/sup><\/em> \u00a0Purkinje cells compared to controls. By complementary approaches <em>in vivo<\/em> and <em>ex vivo<\/em>, the project aims at dissecting and targeting defects in this pathway, to understand their contribution to the ataxic phenotype observed in ARSACS. The final aim is the identification of new valuable targets for therapeutic intervention.<\/span><\/p>\n<p>Grant : $100,000<\/p>\n<p>Duration: One year<\/p>\n<p>Contact:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-234 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrFrancescaMaltecca-150x150-2.jpg\" alt=\"Dr. Francesca Maltecca\" width=\"199\" height=\"199\" \/><\/p>\n<p>Dr. Francesca Maltecc<\/p>\n<p>Universita Vita-Salute San Raffaele<br \/>\nVia Olgettina 60 20132 Milan, Italy<\/p>\n<p><a href=\"mailto:maltecca.francesca@hsr.it\">maltecca.francesca@hsr.it<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We identified in murine Purkinje cells a specific interaction of sacsin with proteins regulating transmembrane ion balance, which are required for tuning the firing properties of these neurons. Our functional studies support a deregulation of ion conductance in Sacs-\/- \u00a0Purkinje cells compared to controls. By complementary approaches in vivo and ex vivo, the project aims [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[87],"tags":[],"class_list":["post-17783","post","type-post","status-publish","format-standard","hentry","category-recherche-2022"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cTargeting transmembrane ion balance to restore Purkinje cell functionality in ARSACS\u201d - Dr. Francesca Maltecca - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/targeting-transmembrane-ion-balance-to-restore-purkinje-cell-functionality-in-arsacs-dr-francesca-maltecca\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cTargeting transmembrane ion balance to restore Purkinje cell functionality in ARSACS\u201d - Dr. Francesca Maltecca - ARSACS\" \/>\n<meta property=\"og:description\" content=\"We identified in murine Purkinje cells a specific interaction of sacsin with proteins regulating transmembrane ion balance, which are required for tuning the firing properties of these neurons. Our functional studies support a deregulation of ion conductance in Sacs-\/- \u00a0Purkinje cells compared to controls. 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