{"id":17792,"date":"2022-10-25T17:43:30","date_gmt":"2022-10-25T21:43:30","guid":{"rendered":"https:\/\/arsacs.com\/?p=17792"},"modified":"2023-10-09T11:17:12","modified_gmt":"2023-10-09T15:17:12","slug":"elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-4","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-4\/","title":{"rendered":"\u201cElucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS\u201d &#8211; Dr. Alanna Watt and Dr. Anne McKinney"},"content":{"rendered":"<p>One of the hallmark features of ARSACS is dysfunction and eventual death of Purkinje cells in the cerebellum, which contributes to ataxia. Strikingly, not all Purkinje cells become ill and die: rather, specific patterns of vulnerability and resilience to cell death are observed in both human patients and mouse models of ARSACs. Our work focuses on identification of the factors that promote resilience or prevent vulnerability to cell death. For example, we recently reported that both the location and molecular profile of Purkinje cells are involved in determining cell survival or death (Toscano-Marquez et al., 2021). We continue this line of research with a focus on three hypotheses: (1) Can improving mitochondria function prevent cell death and reduce ataxia progression? (2) Does a pH regulator act as a therapeutic agent for ARSACs treatment? (3) Do changes in non-neuronal cells impact cerebellar function in ARSACS? Finally, we continue to explore novel pathways that could be targeted for future therapeutics.<\/p>\n<\/p>\n<p>Grant: $191,000 ( second year of a 2 year\u00a0 project)<\/p>\n<p>Duration : one year<\/p>\n<p>Contacts:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-132 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1-150x150-2.jpg\" alt=\"Dr. Alanna Watt\" width=\"200\" height=\"200\" \/><\/p>\n<\/p>\n<p>Dr. Alanna Watt, Department of Biology<\/p>\n<p>McGill University, Bellini Life Sciences Bldg., room 265<br \/>3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1<br \/><a href=\"mailto:alanna.watt@mcgill.ca\">alanna.watt@mcgill.ca<\/a><\/p>\n<\/p>\n<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-186 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Anne-McKinney-150x150-2.jpg\" alt=\"Dr. Anne McKinney\" width=\"200\" height=\"200\" \/><\/p>\n<\/p>\n<p>Dr. Anne McKinney, Department of Pharmacology and Therapeutics<\/p>\n<p>McGill University,\u00a0 Bellini Life Sciences Bldg., room 167<br \/>3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1<br \/>\u00a0<a href=\"mailto:anne.mckinney@mcgill.ca\">anne.mckinney@mcgill.ca<\/a><\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the hallmark features of ARSACS is dysfunction and eventual death of Purkinje cells in the cerebellum, which contributes to ataxia. Strikingly, not all Purkinje cells become ill and die: rather, specific patterns of vulnerability and resilience to cell death are observed in both human patients and mouse models of ARSACs. Our work focuses [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[87],"tags":[],"class_list":["post-17792","post","type-post","status-publish","format-standard","hentry","category-recherche-2022"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cElucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS\u201d - Dr. Alanna Watt and Dr. Anne McKinney - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-4\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cElucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS\u201d - Dr. Alanna Watt and Dr. Anne McKinney - ARSACS\" \/>\n<meta property=\"og:description\" content=\"One of the hallmark features of ARSACS is dysfunction and eventual death of Purkinje cells in the cerebellum, which contributes to ataxia. Strikingly, not all Purkinje cells become ill and die: rather, specific patterns of vulnerability and resilience to cell death are observed in both human patients and mouse models of ARSACs. Our work focuses [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/arsacs.com\/fr\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-4\/\" \/>\n<meta property=\"og:site_name\" content=\"ARSACS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=100044457429916\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-25T21:43:30+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-09T15:17:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1-150x150-2.jpg\" \/>\n<meta name=\"author\" content=\"ARSACS\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ARSACS\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-4\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/elucidating-mechanisms-underlying-motor-coordination-rescue-in-a-mouse-model-of-arsacs-dr-alanna-watt-and-dr-anne-mckinney-4\\\/\"},\"author\":{\"name\":\"ARSACS\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/person\\\/93b66d6b897bfa131622d04b767b15f1\"},\"headline\":\"\u201cElucidating mechanisms underlying motor coordination rescue in a mouse model of ARSACS\u201d &#8211; 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