{"id":17818,"date":"2022-10-25T17:23:37","date_gmt":"2022-10-25T21:23:37","guid":{"rendered":"https:\/\/arsacs.com\/?p=17818"},"modified":"2023-10-09T11:24:19","modified_gmt":"2023-10-09T15:24:19","slug":"identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\/","title":{"rendered":"&#8220;Identifying Clinically Relevant Compounds and Their Molecular Targets Modulating the Purkinje Neuronal Excitability in ARSCAS patients\u201d- Dr.Mohan Babu"},"content":{"rendered":"<p>Despite extensive research, the underlying causes of neurodegeneration in ARSACS still remain unclear, and thus there is a need for identifying effective therapies for ARSACS patients. My lab over the past several years has focused on characterizing the changes of macromolecular assemblies in ARSACS patients, as well as mapping the ARSACS-linked <em>SACS <\/em>pathways, to reveal potential drivers of ARSACS. Aberrant alteration of neuronal excitability contributes to increased calcium influx in neurons, which can lead to neurological disorders, including ARSACS. Therefore, identifying molecular targets modulating excitability in human neurons carrying <em>SACS <\/em>gene mutation in ARSACS patients is a promising first step towards exploring therapeutic interventions. In this newly funded proposal, we will perform a phenotypic screen against annotated compounds in iPSC-derived human neurons carrying the <em>SACS<\/em> ARSACS mutation to identify molecular targets that restore cellular phenotypes of ARSACS, such as altered neuronal excitability, to the normal state. The role of promising excitability modulators will then be interrogated in ARSACS disease pathogenesis. Identification of drugs acting on targets that modulate abnormal excitability should lay the foundation for future drug development programs for ARSACS.<\/p>\n<p>Grant: $100,000<\/p>\n<p>Duration: one year<\/p>\n<p>Contact:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-9128 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrMohanBabu.jpg\" alt=\"Dr. Mohan Babu\" width=\"197\" height=\"221\" \/><\/p>\n<p>Dr.Mohan Babu,Department of Biochemistry<\/p>\n<p>University of Regina<br \/>\nSaskatchewan SK S4S 0A2<br \/>\n<a href=\"mailto:mohan.babu@uregina.ca\">mohan.babu@uregina.ca<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despite extensive research, the underlying causes of neurodegeneration in ARSACS still remain unclear, and thus there is a need for identifying effective therapies for ARSACS patients. My lab over the past several years has focused on characterizing the changes of macromolecular assemblies in ARSACS patients, as well as mapping the ARSACS-linked SACS pathways, to reveal [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[87],"tags":[],"class_list":["post-17818","post","type-post","status-publish","format-standard","hentry","category-recherche-2022"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>&quot;Identifying Clinically Relevant Compounds and Their Molecular Targets Modulating the Purkinje Neuronal Excitability in ARSCAS patients\u201d- Dr.Mohan Babu - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;Identifying Clinically Relevant Compounds and Their Molecular Targets Modulating the Purkinje Neuronal Excitability in ARSCAS patients\u201d- Dr.Mohan Babu - ARSACS\" \/>\n<meta property=\"og:description\" content=\"Despite extensive research, the underlying causes of neurodegeneration in ARSACS still remain unclear, and thus there is a need for identifying effective therapies for ARSACS patients. My lab over the past several years has focused on characterizing the changes of macromolecular assemblies in ARSACS patients, as well as mapping the ARSACS-linked SACS pathways, to reveal [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/arsacs.com\/fr\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\/\" \/>\n<meta property=\"og:site_name\" content=\"ARSACS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=100044457429916\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-25T21:23:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-09T15:24:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrMohanBabu.jpg\" \/>\n<meta name=\"author\" content=\"ARSACS\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ARSACS\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\\\/\"},\"author\":{\"name\":\"ARSACS\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/person\\\/93b66d6b897bfa131622d04b767b15f1\"},\"headline\":\"&#8220;Identifying Clinically Relevant Compounds and Their Molecular Targets Modulating the Purkinje Neuronal Excitability in ARSCAS patients\u201d- Dr.Mohan Babu\",\"datePublished\":\"2022-10-25T21:23:37+00:00\",\"dateModified\":\"2023-10-09T15:24:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\\\/\"},\"wordCount\":224,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/DrMohanBabu.jpg\",\"articleSection\":[\"Recherche 2022\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\\\/\",\"url\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/identifying-clinically-relevant-compounds-and-their-molecular-targets-modulating-the-purkinje-neuronal-excitability-in-arscas-patients-dr-mohan-babu\\\/\",\"name\":\"\\\"Identifying Clinically Relevant Compounds and Their Molecular Targets Modulating the Purkinje Neuronal Excitability in ARSCAS patients\u201d- Dr.Mohan Babu - 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