{"id":18337,"date":"2023-03-19T16:04:17","date_gmt":"2023-03-19T20:04:17","guid":{"rendered":"https:\/\/arsacs.com\/?p=18337"},"modified":"2026-03-16T18:14:56","modified_gmt":"2026-03-16T22:14:56","slug":"dr-chapples-research-using-ai-technology-published","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/dr-chapples-research-using-ai-technology-published\/","title":{"rendered":"Dr. Chapple&#8217;s research using AI technology published"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Dr. Paul Chapple's research article <a href=\"https:\/\/arsacs.com\/wp-content\/uploads\/2023\/03\/Article_Paul-Chapple_Frontiers_2023-01-13_Sacsin-Hsp90-AphaFold.pdf\"><em>\"AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein Sacsin reveals key residues for ATPase activity<\/em>\"<\/a> was published in Frontiers in Molecular Biosciences in January 2023.  The research team  used a new technology, AlphaFold - an AI program which performs predictions of protein structure, to look more closely at Sacsin structure and whether it is really like a Hsp90 molecular chaperone, which the data indicates it is. The research on Sacsin\/ARSACS was supported by grants from the Ataxia Chalevoix-Saguenay Foundation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Dr. Paul Chapple&#8217;s research article &#8220;AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein Sacsin reveals key residues for ATPase activity&#8221; was published in Frontiers in Molecular Biosciences in January 2023. The research team used a new technology, AlphaFold &#8211; an AI program which performs predictions of protein structure, to look more [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":18345,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-18337","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/18337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=18337"}],"version-history":[{"count":5,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/18337\/revisions"}],"predecessor-version":[{"id":24868,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/18337\/revisions\/24868"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media\/18345"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=18337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=18337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=18337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}