{"id":19167,"date":"2023-10-09T11:30:49","date_gmt":"2023-10-09T15:30:49","guid":{"rendered":"https:\/\/arsacs.com\/?p=19167"},"modified":"2026-03-16T18:15:22","modified_gmt":"2026-03-16T22:15:22","slug":"exploring-and-treating-cognitive-dysmetria-in-the-mouse-model-of-arsacs-dr-stefan-strack","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/exploring-and-treating-cognitive-dysmetria-in-the-mouse-model-of-arsacs-dr-stefan-strack\/","title":{"rendered":"&#8220;Exploring and treating cognitive dysmetria in the mouse model of ARSACS\u201d &#8211; Dr Stefan Strack"},"content":{"rendered":"The cerebellum is critical for the coordination of movements and thought processes. Indeed, patient suffering from spinocerebellar ataxias including ARSACS commonly display psychiatric and cognitive symptoms. These cognitive and neuropsychiatric symptoms are often more debilitating than neurological symptoms and therefore deserve increased attention.\n\nThis proposal examines the time course of cognitive and motor dysfunction in the <em>Sacs<\/em> KO mouse model of ARSACS. The proposal is predicated on preliminary findings that short-term memory deficits precede motor deficits by at least three months. We will also explore whether small-molecule drugs currently in development for the treatment of Alzheimer\u2019s disease rescue cognitive deficits in <em>Sacs<\/em> KO mice. Together with drugs that halt or delay degeneration of the cerebellum, we hope that these \u201ccognitive enhancers\u201d will improve quality of life of families afflicted with ARSACS and similar disorders.\n<p class=\"m_-2151711370727717155MsoListParagraph\">Financement: 100 000$<\/p>\nDur\u00e9e:\u00a0 un an\n\nCoordonn\u00e9es:\n\n<img loading=\"lazy\" decoding=\"async\" class=\"size-thumbnail wp-image-228 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/DrStefanStrack-150x150-2.jpg\" alt=\"Dr Stefan Strack\" width=\"150\" height=\"150\" \/>\n\n<span style=\"font-size: revert;\">Dr. Stefan Strack, Dept. Neuroscience &amp; Pharmacology<\/span>\n\nUniversity of Iowa Carver College of Medicine\n2-452 BSB, 51 Newton Rd.,Iowa City, IA 52242 USA\n\nemail: Stefan-strack@uiowa.edu","protected":false},"excerpt":{"rendered":"<p>The cerebellum is critical for the coordination of movements and thought processes. Indeed, patient suffering from spinocerebellar ataxias including ARSACS commonly display psychiatric and cognitive symptoms. These cognitive and neuropsychiatric symptoms are often more debilitating than neurological symptoms and therefore deserve increased attention. This proposal examines the time course of cognitive and motor dysfunction in [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89],"tags":[],"class_list":["post-19167","post","type-post","status-publish","format-standard","hentry","category-recherche-2023"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/19167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=19167"}],"version-history":[{"count":4,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/19167\/revisions"}],"predecessor-version":[{"id":24905,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/19167\/revisions\/24905"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=19167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=19167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=19167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}