{"id":20088,"date":"2024-03-30T18:16:31","date_gmt":"2024-03-30T22:16:31","guid":{"rendered":"https:\/\/arsacs.com\/?p=20088"},"modified":"2024-08-31T14:24:34","modified_gmt":"2024-08-31T18:24:34","slug":"alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\/","title":{"rendered":"\u201cAlterations of SACSIN RNA-binding properties are connected to the development of ARSACS\u201d \u00a0\u2013 Dr. Roberto Giambruno"},"content":{"rendered":"\n<p>Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease mainly characterized by cerebellar ataxia, progressive spasticity and peripheral neuropathy. The disease is caused by mutations in the SACS gene (13q11) that alter the expression of the protein SACSIN. The first signs of the disease occur during childhood and the disease rapidly progresses over the years. Currently, no treatment is available for ARSACS patients, mainly because the SACSIN molecular functions remain elusive. Unfortunately, this is a very challenging aspect caused by the gigantic dimensions of SACSIN that hampers the possibility of performing standard molecular biology experiments.<br>Curiously, many symptoms of ARSACS patients are common to patients affected by other neurodegenerative disorders. Thus, suggesting that these diseases may have common features also at the molecular level. Prompt by this observation, we extensively revised the literature and hypothesized that, similarly to other neurodegenerative disorders, the alteration of the SACSIN biological interactions is the main trigger of cell toxicity. We plan to demonstrate our hypothesis using an ARSACS cellular model, where we will study the connection between SACSIN altered interactions and cell death. Our study will pave the way to an innovative line of research aiming to restore SACSIN physiological interactions in order to prevent cell toxicity. Thus, having the possibility to impair the development and\/or progression of the disease in ARSACS patients.<\/p>\n\n\n\n<p><strong>L&#8217; <a href=\"http:\/\/www.arsacsodv.it\">Organizzazione di volontariato (ODV)<\/a>, est une organisation de b\u00e9n\u00e9voles fond\u00e9e en Italie  par Mme Susanna Deluca et Dr Paolo Arrigoni, membre du Conseil de la Fondation, finance ce preojet de recherche via  Telethon une organisation \u00e0 but non lucratif  qui finance la recherche sur les maladies rares. <\/strong><\/p>\n\n\n\n<p>Financement: 49.991\u20ac<\/p>\n\n\n\n<p class=\"has-text-align-left\">Dur\u00e9e: un an <\/p>\n\n\n\n<p>Coordonn\u00e9es:<\/p>\n\n\n\n<p class=\"has-text-align-left\"><\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:25% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/03\/Roberto_Giambruno.-jpg.jpg\" alt=\"\" class=\"wp-image-20084 size-full\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/03\/Roberto_Giambruno.-jpg.jpg 200w, https:\/\/arsacs.com\/wp-content\/uploads\/2024\/03\/Roberto_Giambruno.-jpg-150x150.jpg 150w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-text-align-left\">Dr. Roberto Giambruno<\/p>\n\n\n\n<p class=\"has-text-align-left\">Consiglio Nazionale delle Ricerche \u2013<\/p>\n\n\n\n<p class=\"has-text-align-left\">CNR, Istituto per la Ricerca e l\u2019Innovazione Biomedica (IRIB)<\/p>\n\n\n\n<p class=\"has-text-align-left\">Palermo, Sicilia , Italy<\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-center\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease mainly characterized by cerebellar ataxia, progressive spasticity and peripheral neuropathy. The disease is caused by mutations in the SACS gene (13q11) that alter the expression of the protein SACSIN. The first signs of the disease occur during childhood and the disease rapidly progresses over [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[89],"tags":[],"class_list":["post-20088","post","type-post","status-publish","format-standard","hentry","category-recherche-2023"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cAlterations of SACSIN RNA-binding properties are connected to the development of ARSACS\u201d \u00a0\u2013 Dr. Roberto Giambruno - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cAlterations of SACSIN RNA-binding properties are connected to the development of ARSACS\u201d \u00a0\u2013 Dr. Roberto Giambruno - ARSACS\" \/>\n<meta property=\"og:description\" content=\"Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease mainly characterized by cerebellar ataxia, progressive spasticity and peripheral neuropathy. The disease is caused by mutations in the SACS gene (13q11) that alter the expression of the protein SACSIN. The first signs of the disease occur during childhood and the disease rapidly progresses over [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/arsacs.com\/fr\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\/\" \/>\n<meta property=\"og:site_name\" content=\"ARSACS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/profile.php?id=100044457429916\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-30T22:16:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-31T18:24:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/03\/Roberto_Giambruno.-jpg.jpg\" \/>\n<meta name=\"author\" content=\"ARSACS\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"ARSACS\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\\\/\"},\"author\":{\"name\":\"ARSACS\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/#\\\/schema\\\/person\\\/93b66d6b897bfa131622d04b767b15f1\"},\"headline\":\"\u201cAlterations of SACSIN RNA-binding properties are connected to the development of ARSACS\u201d \u00a0\u2013 Dr. Roberto Giambruno\",\"datePublished\":\"2024-03-30T22:16:31+00:00\",\"dateModified\":\"2024-08-31T18:24:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\\\/\"},\"wordCount\":314,\"publisher\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/arsacs.com\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Roberto_Giambruno.-jpg.jpg\",\"articleSection\":[\"Recherche 2023\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\\\/\",\"url\":\"https:\\\/\\\/arsacs.com\\\/fr\\\/alterations-of-sacsin-rna-binding-properties-are-connected-to-the-development-of-arsacs-dr-roberto-giambruno\\\/\",\"name\":\"\u201cAlterations of SACSIN RNA-binding properties are connected to the development of ARSACS\u201d \u00a0\u2013 Dr. Roberto Giambruno - 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