{"id":21148,"date":"2024-08-31T12:05:05","date_gmt":"2024-08-31T16:05:05","guid":{"rendered":"https:\/\/arsacs.com\/?p=21148"},"modified":"2026-03-16T18:16:35","modified_gmt":"2026-03-16T22:16:35","slug":"avatar-mouse-model-of-a-new-genetic-variant-of-arsacs-detected-in-uruguay-dr-martina-crispo-benedetto","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/avatar-mouse-model-of-a-new-genetic-variant-of-arsacs-detected-in-uruguay-dr-martina-crispo-benedetto\/","title":{"rendered":"&#8220;Avatar mouse model of a new genetic variant of ARSACS detected in Uruguay&#8221; &#8211; Dr. Martina Crispo Benedetto"},"content":{"rendered":"<p>\u201cOur goal is to generate an AVATAR mouse model to reproduce the heterozygous compound alteration of a Uruguayan-child, in South America. Using the CRISPR\/Cas technology we will generate a frameshift SACS variant mouse line, reproducing the father\u2019s modification and other mouse line with a missense PRO2369LEU VARIANT for the mother. Obtaining this grant allows us to validate the animal model and initiate pre-clinical studies of this disease in our country in a near future.\u201d<\/p>\n<p><strong>New this year - Seed Grant Project ! <br \/><\/strong><\/p>\n<p>\u00a0Subvention : $25 000<\/p>\n<p style=\"text-align: left;\">Dur\u00e9e : un an<\/p>\n<p>Contact :<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-21151 size-medium\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/08\/Martina-Crispo-300x193.jpg\" alt=\"\" width=\"300\" height=\"193\" \/><\/p>\n<p>From left to right: Geraldine Schlapp, Martina Crispo, Mar\u00eda Noel Meikle, Jorge Luis P\u00f3rfido<\/p>\n<p>Dr. Martina Crispo Benedetto<\/p>\n<p>Mataojo 2020<br \/>Institut Pasteur of Montevideo\u00a0 <br \/>Montevideo, Uruguay<br \/>crispo@pasteur.edu.uy<\/p>\n<p style=\"text-align: center;\">\u00a0<\/p>\n\n\n\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>\u201cOur goal is to generate an AVATAR mouse model to reproduce the heterozygous compound alteration of a Uruguayan-child, in South America. Using the CRISPR\/Cas technology we will generate a frameshift SACS variant mouse line, reproducing the father\u2019s modification and other mouse line with a missense PRO2369LEU VARIANT for the mother. Obtaining this grant allows us [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[90],"tags":[],"class_list":["post-21148","post","type-post","status-publish","format-standard","hentry","category-research-in-2024"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/21148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=21148"}],"version-history":[{"count":8,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/21148\/revisions"}],"predecessor-version":[{"id":25002,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/21148\/revisions\/25002"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=21148"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=21148"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=21148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}