{"id":21164,"date":"2024-08-31T14:44:13","date_gmt":"2024-08-31T18:44:13","guid":{"rendered":"https:\/\/arsacs.com\/?p=21164"},"modified":"2025-09-24T15:37:24","modified_gmt":"2025-09-24T19:37:24","slug":"structural-determination-of-sacsin-dr-walid-houry-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/structural-determination-of-sacsin-dr-walid-houry-2\/","title":{"rendered":"\u201cStructural Determination of Sacsin\u201d- Dr Walid Houry"},"content":{"rendered":"<p>\u00a0<\/p>\n<p>Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a non-treatable neurodegenerative genetic disorder of early childhood and adulthood. When first reported in 1978, ARSACS was described as a unique form of ataxia, accompanied with motor speech anomalies, muscle wasting phenotypes, and peripheral nerve complications. ARSACS symptoms worsen in adulthood, with most individuals losing the ability to walk by the age of 50. Genetic studies have established that ARSACS is caused by mutations in Sacsin \u2013 a protein whose biology is poorly known. Current research suggests that Sacsin supports cytoskeletal and mitochondrial organization. To shed light on Sacsin function, one needs to study Sacsin structure in both native and mutated states. However, no published research has described the purification of Sacsin protein for <em>in vitro<\/em> and structural investigations. This technical gap in research is due to the large size of Sacsin (~520 kDa). Our laboratory has now solved this issue. We have carried out early <em>in vitro<\/em> characterizations of Sacsin, and we are working to obtain its three-dimensional (3D) structure using cryogenic electron microscopy. Our current focus is to increase the resolution of our 3D model and, subsequently, begin <em>in silico<\/em> drug screening.<\/p>\n<p>Financement: 100 000$<\/p>\n<p>Dur\u00e9e : un an<\/p>\n<p>Coordonn\u00e9es:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft  wp-image-6572\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Walid_Houry_University_Toronto-e1606423339816.jpg\" alt=\"\" width=\"201\" height=\"237\" \/><\/p>\n<p>Dr. Walid A. Houry, Department of Biochemistry, Temerty Faculty of Medicine<\/p>\n<p>University of Toronto<br \/>661 University Avenue, Mars Centre, West Tower, Room 1612<\/p>\n<p><span style=\"font-size: revert;\">Toronto, ON Canada M5G 1M1<\/span><\/p>\n<p><a href=\"mailto:walid.houry@utoronto.ca\">walid.houry@utoronto.ca<\/a><\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a non-treatable neurodegenerative genetic disorder of early childhood and adulthood. When first reported in 1978, ARSACS was described as a unique form of ataxia, accompanied with motor speech anomalies, muscle wasting phenotypes, and peripheral nerve complications. ARSACS symptoms worsen in adulthood, with most individuals losing the [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[91],"tags":[],"class_list":["post-21164","post","type-post","status-publish","format-standard","hentry","category-recherche-2024"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cStructural Determination of Sacsin\u201d- Dr Walid Houry - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/structural-determination-of-sacsin-dr-walid-houry-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cStructural Determination of Sacsin\u201d- Dr Walid Houry - ARSACS\" \/>\n<meta property=\"og:description\" content=\"\u00a0 Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a non-treatable neurodegenerative genetic disorder of early childhood and adulthood. 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