{"id":21172,"date":"2024-08-31T14:39:02","date_gmt":"2024-08-31T18:39:02","guid":{"rendered":"https:\/\/arsacs.com\/?p=21172"},"modified":"2025-09-24T16:10:55","modified_gmt":"2025-09-24T20:10:55","slug":"discovering-whole-blood-dna-methylation-biomarkers-of-arsacs-progression-drs-daniele-galatolo-et-de-rosi","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/discovering-whole-blood-dna-methylation-biomarkers-of-arsacs-progression-drs-daniele-galatolo-et-de-rosi\/","title":{"rendered":"\u201cDiscovering whole blood DNA methylation biomarkers of ARSACS progression&#8221;- Drs Daniele Galatolo et Giulia De Rosi"},"content":{"rendered":"<p>The overall aim of this project is to identify the potential role of DNA methylation changes as biomarker of ARSACS progression. We previously demonstrated that patients affected by ARSACS showed changes in DNA methylation pattern, indicating that epigenetics might have a role in disease pathogenesis. These findings encouraged us to get deeper in this field and hypothesize that changes in DNA methylation could constitute a biomarker of disease progression. To achieve our aim, we will analyze the most biologically significant regions of the human methylome in a large group of patients in the context of patients&#8217; clinical history and disease progression.<\/p>\n<p>Financement : 49 500$<\/p>\n<p>Dur\u00e9e : un an<\/p>\n<p>Contact:<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-15770 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/10\/Daniele-Galatolo-photo-201x300.jpg\" alt=\"\" width=\"201\" height=\"300\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/10\/Daniele-Galatolo-photo-201x300.jpg 201w, https:\/\/arsacs.com\/wp-content\/uploads\/2021\/10\/Daniele-Galatolo-photo.jpg 408w\" sizes=\"(max-width: 201px) 100vw, 201px\" \/><\/p>\n<p>Dr. Daniele Galatolo<\/p>\n<p>Molecular Medicine for Neurodegenerative and Neuromuscular Diseases Unit<\/p>\n<p>IRCCS Stella Maris Foundation<br \/>via dei Giacinti 2,<\/p>\n<p>56128 Calambrone (Pisa) &#8211; Italy<\/p>\n<p><a href=\"mailto:daniele.galatolo@fsm.unipi.it\">daniele.galatolo@fsm.unipi.it<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>Dr. Giulia De Rosi<\/p>\n<p>Chercheure <\/p>\n<p><!--more--><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-21107\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/08\/Giulia-De-Riso--225x300.jpg\" alt=\"\" width=\"225\" height=\"300\" \/><\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The overall aim of this project is to identify the potential role of DNA methylation changes as biomarker of ARSACS progression. We previously demonstrated that patients affected by ARSACS showed changes in DNA methylation pattern, indicating that epigenetics might have a role in disease pathogenesis. These findings encouraged us to get deeper in this field [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[91],"tags":[],"class_list":["post-21172","post","type-post","status-publish","format-standard","hentry","category-recherche-2024"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cDiscovering whole blood DNA methylation biomarkers of ARSACS progression&quot;- Drs Daniele Galatolo et Giulia De Rosi - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/discovering-whole-blood-dna-methylation-biomarkers-of-arsacs-progression-drs-daniele-galatolo-et-de-rosi\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cDiscovering whole blood DNA methylation biomarkers of ARSACS progression&quot;- Drs Daniele Galatolo et Giulia De Rosi - ARSACS\" \/>\n<meta property=\"og:description\" content=\"The overall aim of this project is to identify the potential role of DNA methylation changes as biomarker of ARSACS progression. We previously demonstrated that patients affected by ARSACS showed changes in DNA methylation pattern, indicating that epigenetics might have a role in disease pathogenesis. 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