{"id":21202,"date":"2024-08-31T14:23:16","date_gmt":"2024-08-31T18:23:16","guid":{"rendered":"https:\/\/arsacs.com\/?p=21202"},"modified":"2025-09-24T16:09:03","modified_gmt":"2025-09-24T20:09:03","slug":"avatar-mouse-model-of-a-new-genetic-variant-of-arsacs-detected-in-uruguay-dre-martina-crispo-benedetto","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/avatar-mouse-model-of-a-new-genetic-variant-of-arsacs-detected-in-uruguay-dre-martina-crispo-benedetto\/","title":{"rendered":"\u201cAvatar mouse model of a new genetic variant of ARSACS detected in Uruguay&#8221;- Dre Martina Crispo Benedetto"},"content":{"rendered":"\n<p><\/p>\n\n\n<p>Our goal is to generate an AVATAR mouse model to reproduce the heterozygous compound alteration of a Uruguayan-child, in South America. Using the CRISPR\/Cas technology we will generate a frameshift SACS variant mouse line, reproducing the father\u2019s modification and other mouse line with a missense PRO2369LEU VARIANT for the mother. Obtaining this grant allows us to validate the animal model and initiate pre-clinical studies of this disease in our country in a near future.<\/p>\n<p><strong>Nouveau cette ann\u00e9e !\u00a0 Financement de d\u00e9marage\u00a0 (Seed money) <br \/><\/strong><\/p>\n<p>Financement : 25 000$<\/p>\n<p>Dur\u00e9e: un an<\/p>\n<p>Coordonn\u00e9es:<\/p>\n<p style=\"text-align: left;\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-21152 size-medium\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/08\/Martina-Crispo-300x193.jpg\" alt=\"\" width=\"300\" height=\"193\" \/><\/p>\n<p style=\"text-align: left;\">De g \u00e0 dr: Geraldine Schlapp, Martina Crispo, Mar\u00eda Noel Meikle, Jorge Luis P\u00f3rfido<\/p>\n<p>Dre Martina Crispo Benedetto<\/p>\n<p>Mataojo 2020<br \/>Institut Pasteur of Montevideo <br \/>Montevideo, Uruguay<br \/>crispo@pasteur.edu. uy<\/p>\n<p>\u00a0<\/p>\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-left\"><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our goal is to generate an AVATAR mouse model to reproduce the heterozygous compound alteration of a Uruguayan-child, in South America. Using the CRISPR\/Cas technology we will generate a frameshift SACS variant mouse line, reproducing the father\u2019s modification and other mouse line with a missense PRO2369LEU VARIANT for the mother. Obtaining this grant allows us [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[91],"tags":[],"class_list":["post-21202","post","type-post","status-publish","format-standard","hentry","category-recherche-2024"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cAvatar mouse model of a new genetic variant of ARSACS detected in Uruguay&quot;- Dre Martina Crispo Benedetto - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/avatar-mouse-model-of-a-new-genetic-variant-of-arsacs-detected-in-uruguay-dre-martina-crispo-benedetto\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cAvatar mouse model of a new genetic variant of ARSACS detected in Uruguay&quot;- Dre Martina Crispo Benedetto - ARSACS\" \/>\n<meta property=\"og:description\" content=\"Our goal is to generate an AVATAR mouse model to reproduce the heterozygous compound alteration of a Uruguayan-child, in South America. Using the CRISPR\/Cas technology we will generate a frameshift SACS variant mouse line, reproducing the father\u2019s modification and other mouse line with a missense PRO2369LEU VARIANT for the mother. 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