{"id":22596,"date":"2025-09-24T12:35:52","date_gmt":"2025-09-24T16:35:52","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22596"},"modified":"2026-03-16T18:18:11","modified_gmt":"2026-03-16T22:18:11","slug":"approches-therapeutiques-de-larsacs-les-docteurs-benoit-gentil-et-heather-durham-4","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-drs-benoit-gentil-and-heather-durham-4\/","title":{"rendered":"\u201c Approches th\u00e9rapeutiques de l\u2019ARSACS \u201d \u2013 Dr Benoit Gentil et Dr Heather Durham"},"content":{"rendered":"

Cette recherche porte sur le d\u00e9veloppement d'une th\u00e9rapie g\u00e9nique potentielle contre l'ARSACS, une maladie neurologique h\u00e9r\u00e9ditaire rare. Les scientifiques ont cr\u00e9\u00e9 une version plus petite de la prot\u00e9ine d\u00e9fectueuse (appel\u00e9e\u00a0minisacsin<\/i>) pouvant \u00eatre int\u00e9gr\u00e9e dans un vecteur viral en vue de son administration aux cellules nerveuses. Dans des mod\u00e8les murins, un traitement pr\u00e9coce par cette th\u00e9rapie a retard\u00e9 ou att\u00e9nu\u00e9 les sympt\u00f4mes de la maladie, notamment les troubles moteurs et les alt\u00e9rations r\u00e9tiniennes. L\u2019\u00e9quipe cherche d\u00e9sormais \u00e0 d\u00e9terminer si cette th\u00e9rapie peut \u00e9galement \u00eatre b\u00e9n\u00e9fique apr\u00e8s l\u2019apparition des sympt\u00f4mes.\u00a0 Nos r\u00e9sultats obtenus \u00e0 ce jour permettent de mieux comprendre la pathogen\u00e8se de l\u2019ARSACS et permettraient de mener \u00e0 bien les \u00e9tudes pr\u00e9cliniques visant \u00e0 d\u00e9velopper une th\u00e9rapie g\u00e9nique contre l\u2019ARSACS.<\/p>\n

Subvention : $100 000<\/p>\n

Dur\u00e9e : un an<\/p>\n

\"\"<\/p>\n

Le Dr Benoit Gentil et le Dr Heather Durham<\/p>\n

D\u00e9partement de kin\u00e9siologie et d'\u00e9ducation physique, Universit\u00e9 McGill\u00a0<\/span><\/p>\n

475, avenue Pine Ouest, bureau 210<\/p>\n

Montr\u00e9al (Qu\u00e9bec) H2W 1S4<\/p>\n

Contacts : heather.durham@mcgill.ca<\/a> ; \u00a0\u00a0benoit.gentil@mcgill.ca<\/a><\/p>\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

This research focuses on developing a potential gene therapy for ARSACS, a rare inherited neurological disease. Scientists created a smaller version of the faulty protein (called\u00a0minisacsin) that can fit into a viral vector for delivery to nerve cells. In mouse models, early treatment with this therapy delayed or reduced disease symptoms, including movement problems and […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22596","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22596"}],"version-history":[{"count":6,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22596\/revisions"}],"predecessor-version":[{"id":25126,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22596\/revisions\/25126"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}