{"id":22600,"date":"2025-09-24T12:34:25","date_gmt":"2025-09-24T16:34:25","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22600"},"modified":"2026-03-16T18:18:09","modified_gmt":"2026-03-16T22:18:09","slug":"developpement-de-modeles-murins-conditionnels-et-de-nouvelles-approches-therapeutiques-pour-traiter-larsacs-dr-stefan-strack-2-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2-2\/","title":{"rendered":"\u201c D\u00e9veloppement de mod\u00e8les murins conditionnels et de nouvelles approches th\u00e9rapeutiques pour l'ARSACS \u201d \u2013 Dr Stefan Strack"},"content":{"rendered":"<p>Ce <em>Sacs<\/em> La souris \u00ab knock-out \u00bb (KO) constitue un mod\u00e8le fid\u00e8le de l'ARSACS, pr\u00e9sentant une ataxie, une faiblesse musculaire, une d\u00e9g\u00e9n\u00e9rescence c\u00e9r\u00e9belleuse et, comme nous l'avons r\u00e9cemment d\u00e9montr\u00e9, des troubles de l'apprentissage et de la m\u00e9moire. Dans le cadre de cette proposition, nous cherchons \u00e0 restaurer par voie pharmacologique les ph\u00e9notypes moteurs et cognitifs chez la <em>Sacs<\/em> Mod\u00e8le KO de l'ARSACS utilisant un m\u00e9dicament qui augmente les taux d'un second messager (AMPc) dans le cerveau et qui fait actuellement l'objet d'essais cliniques de phase 2 et de phase 3 pour deux troubles neurod\u00e9veloppementaux. Deuxi\u00e8mement, nous proposons de d\u00e9velopper une th\u00e9rapie g\u00e9nique pour l'ARSACS. Troisi\u00e8mement, nous avons g\u00e9n\u00e9r\u00e9 un mod\u00e8le conditionnel <em>Sacs<\/em> Le mod\u00e8le KO, que nous utiliserons pour d\u00e9terminer o\u00f9 et quand <em>Sacs<\/em> La perte de fonction est \u00e0 l'origine de l'ensemble des sympt\u00f4mes de l'ARSACS.\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>Subvention : $100 000<\/p>\n<p style=\"text-align: left;\">Dur\u00e9e : un an<\/p>\n<p>\u00a0<\/p>\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:19% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"180\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2023\/09\/Strack.jpg\" alt=\"\" class=\"wp-image-19043 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\">Dr Stefan Strack, D\u00e9partement des neurosciences et de pharmacologie<br>Facult\u00e9 de m\u00e9decine Carver de l'Universit\u00e9 de l'Iowa<br>2-452 BSB, 51 Newton Rd., Iowa City, IA 52242<br>stefan-strack@uiowa.edu<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Contact :   <a href=\"mailto:stefan-strack@uiowa.edu\">stefan-strack@uiowa.edu<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the Sacs KO model of ARSACS with a drug that raises levels of a second [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22600","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22600"}],"version-history":[{"count":7,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22600\/revisions"}],"predecessor-version":[{"id":25124,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22600\/revisions\/25124"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}