{"id":22616,"date":"2025-09-24T12:32:04","date_gmt":"2025-09-24T16:32:04","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22616"},"modified":"2026-03-16T18:18:07","modified_gmt":"2026-03-16T22:18:07","slug":"exploring-the-contributions-of-dcn-alterations-to-cerebellar-dysfunction-in-arsacs-dr-alanna-watt","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/exploring-the-contributions-of-dcn-alterations-to-cerebellar-dysfunction-in-arsacs-dr-alanna-watt\/","title":{"rendered":"\u201c \u00c9tude du r\u00f4le des alt\u00e9rations du r\u00e9seau DCN dans le dysfonctionnement c\u00e9r\u00e9belleux chez les patients atteints du syndrome d\u2019ARSACS \u201d \u2013 Dr Alanna Watt"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In ARSACS, the cerebellum, critical for coordination and balance, is one of the most affected brain regions. Within the cerebellum, communication between Purkinje cells and the cerebellar nuclei, which helps integrate signals and execute coordinated movements, begins to break down early in the disease. Around the same time, inflammation appear in the cerebellar nuclei, suggesting that the support cells, called glial cells, become unusually active and may contribute to this disruption. Our research investigates whether this early inflammation and breakdown in communication contributes to later Purkinje cell death. We aim to understand how these connections deteriorate and test if preventing this process can protect Purkinje cells and preserve motor coordination.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Subvention : $100 000<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dur\u00e9e : un an<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:19% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"207\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1.jpg\" alt=\"\" class=\"wp-image-10759 size-full\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1.jpg 200w, https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1-193x200.jpg 193w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\">Dr. Alanna Watt<br>Department of Biology<br>Bellini Life Sciences Building, Room 265<br>3649 Sir William Osler<br>Montreal, QC H3G OB1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Contact : <a href=\"mailto:alanna.watt@mcgill.ca\">alanna.watt@mcgill.ca<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In ARSACS, the cerebellum, critical for coordination and balance, is one of the most affected brain regions. Within the cerebellum, communication between Purkinje cells and the cerebellar nuclei, which helps integrate signals and execute coordinated movements, begins to break down early in the disease. Around the same time, inflammation appear in the cerebellar nuclei, suggesting [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22616","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22616"}],"version-history":[{"count":6,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22616\/revisions"}],"predecessor-version":[{"id":25121,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22616\/revisions\/25121"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}