{"id":22642,"date":"2025-09-24T12:36:32","date_gmt":"2025-09-24T16:36:32","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22642"},"modified":"2026-03-16T18:18:12","modified_gmt":"2026-03-16T22:18:12","slug":"tests-therapeutiques-evolutifs-chez-la-souris-arsacs-dr-justin-wolter-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/scalable-therapeutic-testing-in-the-arsacs-mouse-dr-justin-wolter-2\/","title":{"rendered":"\u201c Tests th\u00e9rapeutiques \u00e9volutifs chez la souris ARSACS \u201d \u2013 Drs Justin Wolter et Huaxia Wang"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Notre projet vise \u00e0 acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments pour l'ARSACS en utilisant une technique avanc\u00e9e de s\u00e9quen\u00e7age de l'ARN mononucl\u00e9aire (snRNAseq) afin de tester huit candidats th\u00e9rapeutiques sur le mod\u00e8le murin de l'ARSACS (notamment dans le cadre d'\u00e9tudes en cours men\u00e9es par les Drs Gentil\/Durham et les Drs Lim\/Schmahmann). Contrairement aux m\u00e9thodes traditionnelles qui reposent sur des tests comportementaux variables et de longue dur\u00e9e, notre approche mesure directement les modifications mol\u00e9culaires et cellulaires au sein des principaux types de cellules c\u00e9r\u00e9brales touch\u00e9es par l\u2019ARSACS, ce qui permet d\u2019obtenir des \u00e9valuations plus pr\u00e9cises et plus facilement transposables des effets des m\u00e9dicaments. En identifiant la mani\u00e8re dont chaque m\u00e9dicament modifie l\u2019expression g\u00e9nique et les populations cellulaires li\u00e9es \u00e0 la progression de la maladie, nous pouvons hi\u00e9rarchiser les traitements les plus prometteurs en vue de leur d\u00e9veloppement ult\u00e9rieur. Ces travaux visent \u00e0 rationaliser et \u00e0 am\u00e9liorer les essais pr\u00e9cliniques, afin, \u00e0 terme, de contribuer \u00e0 mettre plus rapidement \u00e0 la disposition de la communaut\u00e9 des personnes atteintes de l'ARSACS des traitements efficaces.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Subvention : $100 000<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Dur\u00e9e : premi\u00e8re ann\u00e9e d'un projet de trois ans<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ce projet a \u00e9t\u00e9 cofinanc\u00e9 par le Fonds fiduciaire Richardson, qui a apport\u00e9 une contribution de 50 000$.<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:15% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/10\/Wolter-headshot-3-683x1024.jpeg\" alt=\"\" class=\"wp-image-21478 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr Justin Wolter<br>425, Henry Mall<br>Madison, Wisconsin<br>53706<br>\u00c9tats-Unis<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Contact : <a href=\"mailto:wolter4@wisc.edu\">wolter4@wisc.edu<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:16% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"256\" height=\"256\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/10\/people-huaxia-headshot-6.jpeg\" alt=\"\" class=\"wp-image-21494 size-full\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/10\/people-huaxia-headshot-6.jpeg 256w, https:\/\/arsacs.com\/wp-content\/uploads\/2024\/10\/people-huaxia-headshot-6-150x150.jpeg 150w\" sizes=\"(max-width: 256px) 100vw, 256px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Dr Huaxia Wang<br>425, Henry Mall<br>Madison, Wisconsin<br>53706<br>\u00c9tats-Unis<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Our project aims to accelerate drug discovery for ARSACS by using advanced single nucleus RNA sequencing (snRNAseq) to test 8 therapeutic candidates in the ARSACS mouse model (including ongoing studies led by Drs. Gentil\/Durham, and Drs. Lim\/Schmahmann). Unlike traditional methods that rely on variable and lengthy behavioral tests, our approach directly measures molecular and cellular [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22642","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22642"}],"version-history":[{"count":13,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22642\/revisions"}],"predecessor-version":[{"id":25127,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22642\/revisions\/25127"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22642"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22642"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}