{"id":22694,"date":"2025-09-25T14:31:24","date_gmt":"2025-09-25T18:31:24","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22694"},"modified":"2026-03-16T18:18:19","modified_gmt":"2026-03-16T22:18:19","slug":"structural-determination-of-sacsin-dr-walid-houry-3","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/structural-determination-of-sacsin-dr-walid-houry-3\/","title":{"rendered":"\u201cStructural Determination of Sacsin\u201d- Dr Walid Houry"},"content":{"rendered":"<p>L'ataxie spastique autosomique r\u00e9cessive de Charlevoix-Saguenay (ARSACS) a \u00e9t\u00e9 d\u00e9crite en 1978 comme une forme unique d'ataxie s'accompagnant d'anomalies de la parole d'origine motrice, de ph\u00e9notypes de fonte musculaire et de complications au niveau des nerfs p\u00e9riph\u00e9riques. Des \u00e9tudes g\u00e9n\u00e9tiques ont \u00e9tabli que l\u2019ARSACS est caus\u00e9e par des mutations de la sacsin, une prot\u00e9ine dont la biologie est mal connue. Les recherches actuelles sugg\u00e8rent que la sacsin contribue \u00e0 l\u2019organisation du cytosquelette et des mitochondries. Afin de mieux comprendre la fonction de la sacsin et de favoriser le d\u00e9veloppement futur de traitements potentiels, il est n\u00e9cessaire de d\u00e9terminer la structure de la sacsin, tant \u00e0 l\u2019\u00e9tat natif qu\u2019\u00e0 l\u2019\u00e9tat mut\u00e9. Cependant, aucune \u00e9tude publi\u00e9e n\u2019a d\u00e9crit la purification de la sacsin, une prot\u00e9ine de 520 kDa, pour <em>in vitro<\/em> et des \u00e9tudes structurales. Notre groupe s'efforce actuellement d'optimiser les conditions d'expression et de purification de la saccine. Nous travaillons \u00e9galement \u00e0 la d\u00e9termination de sa structure tridimensionnelle (3D) \u00e0 l'aide de la microscopie \u00e9lectronique cryog\u00e9nique.<\/p>\n<p>Financement: 100 000$<\/p>\n<p>Dur\u00e9e : un an<\/p>\n<p>\u00a0<\/p>\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:24% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"127\" height=\"150\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Walid_Houry_University_Toronto-e1606423339816.jpg\" alt=\"\" class=\"wp-image-11530 size-full\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\">Dr. Walid A. Houry<br>Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto<br>661 University Avenue, Mars Centre, West Tower, Room 1612<br>Toronto, ON, Canada M5G 1M1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Coordonn\u00e9es :\u00a0\u00a0<a href=\"mailto:walid.houry@utoronto.ca\">walid.houry@utoronto.ca<\/a><\/p>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) was described in 1978 as a unique form of ataxia accompanied with motor speech anomalies, muscle wasting phenotypes, and peripheral nerve complications. Genetic studies have established that ARSACS is caused by mutations in sacsin \u2013 a protein whose biology is poorly known. Current research suggests that sacsin supports [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-22694","post","type-post","status-publish","format-standard","hentry","category-projets-de-recherche"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22694"}],"version-history":[{"count":3,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22694\/revisions"}],"predecessor-version":[{"id":25135,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22694\/revisions\/25135"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}