{"id":22696,"date":"2025-09-25T14:32:59","date_gmt":"2025-09-25T18:32:59","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22696"},"modified":"2025-09-25T14:32:59","modified_gmt":"2025-09-25T18:32:59","slug":"therapeutic-approaches-for-arsacs-dr-benoit-gentil-et-dre-heather-durham","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-et-dre-heather-durham\/","title":{"rendered":"\u201cTherapeutic Approaches for ARSACS\u201d- Dr Benoit Gentil et Dre Heather Durham"},"content":{"rendered":"<p>This research focuses on developing a potential gene therapy for ARSACS, a rare inherited neurological disease. Scientists created a smaller version of the faulty protein (called\u00a0<i>minisacsin<\/i>) that can fit into a viral vector for delivery to nerve cells. In mouse models, early treatment with this therapy delayed or reduced disease symptoms, including movement problems and retinal changes. The team is now testing whether the therapy can also help after symptoms begin.\u00a0 Our results so far provide a better understanding of the ARSACS pathogenesis would complete preclinical studies aiming at developing \u00a0a gene therapy for ARSACS.<\/p>\n<p>Financement : 100 000$<\/p>\n<p>Dur\u00e9e: un an<\/p>\n<p style=\"text-align: left;\">\u00a0<\/p>\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:37% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"685\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Durham_Benoit_Nov_2017.jpg\" alt=\"\" class=\"wp-image-9816 size-full\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Durham_Benoit_Nov_2017.jpg 1024w, https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Durham_Benoit_Nov_2017-980x656.jpg 980w, https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Durham_Benoit_Nov_2017-480x321.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>Dre Heather Durham et Dr Benoit Gentil<br>D\u00e9partement of Kin\u00e9siologie et \u00c9ducation Physique,  Universit\u00e9 McGill<br>475 Pine Avenue West, salle 210<br>Montr\u00e9al, Qu\u00e9bec\u00a0 H3A 2B4<\/p>\n\n\n\n<p>Coordonn\u00e9es:<a href=\"mailto:heather.durham@mcgill.ca\">heather.durham@mcgill.ca<\/a> ;\u00a0\u00a0<a href=\"mailto:benoit.gentil@mcgill.ca\">benoit.gentil@mcgill.ca<\/a><\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-left\"><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This research focuses on developing a potential gene therapy for ARSACS, a rare inherited neurological disease. Scientists created a smaller version of the faulty protein (called\u00a0minisacsin) that can fit into a viral vector for delivery to nerve cells. In mouse models, early treatment with this therapy delayed or reduced disease symptoms, including movement problems and [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-22696","post","type-post","status-publish","format-standard","hentry","category-projets-de-recherche"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u201cTherapeutic Approaches for ARSACS\u201d- Dr Benoit Gentil et Dre Heather Durham - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/therapeutic-approaches-for-arsacs-dr-benoit-gentil-et-dre-heather-durham\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u201cTherapeutic Approaches for ARSACS\u201d- Dr Benoit Gentil et Dre Heather Durham - ARSACS\" \/>\n<meta property=\"og:description\" content=\"This research focuses on developing a potential gene therapy for ARSACS, a rare inherited neurological disease. Scientists created a smaller version of the faulty protein (called\u00a0minisacsin) that can fit into a viral vector for delivery to nerve cells. 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