{"id":22700,"date":"2025-09-25T14:33:17","date_gmt":"2025-09-25T18:33:17","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22700"},"modified":"2025-09-25T14:33:17","modified_gmt":"2025-09-25T18:33:17","slug":"developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2\/","title":{"rendered":"“Developing conditional mouse models and new approaches to treating ARSACS\u201d – Dr Stefan Strack"},"content":{"rendered":"

The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the Sacs KO model of ARSACS with a drug that raises levels of a second messenger (cAMP) in the brain and that is currently in phase 2 and phase 3 clinical trials for two neurodevelopmental disorders. Second, we propose to develop gene therapy for ARSACS. Third, we have generated a conditional Sacs KO model, which we will use to pinpoint where and when Sacs loss-of-function causes the spectrum of ARSACS symptoms.<\/p>\n

Financement: 100 000$<\/p>\n

Dur\u00e9e:\u00a0 un an<\/p>\n

\u00a0<\/p>\n\n\n

\"\"<\/figure>
\n

Dr Stefan Strack
Dept. Neuroscience & Pharmacologie
University of lowa Carver College of Medicine
2-452 BSB, 51 Newton Rd.
lowa City, IA 52242 USA<\/p>\n\n\n\n

Coordonn\u00e9es:Stefan-strack@uiowa.edu<\/a><\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the Sacs KO model of ARSACS with a drug that raises levels of a second […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-22700","post","type-post","status-publish","format-standard","hentry","category-projets-de-recherche"],"yoast_head":"\n"Developing conditional mouse models and new approaches to treating ARSACS\u201d - Dr Stefan Strack - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\""Developing conditional mouse models and new approaches to treating ARSACS\u201d - Dr Stefan Strack - ARSACS\" \/>\n<meta property=\"og:description\" content=\"The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. 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