{"id":22700,"date":"2026-09-11T09:33:17","date_gmt":"2026-09-11T13:33:17","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22700"},"modified":"2026-09-11T09:35:09","modified_gmt":"2026-09-11T13:35:09","slug":"developpement-de-modeles-murins-conditionnels-et-de-nouvelles-approches-therapeutiques-pour-le-traitement-de-larsacs-dr-stefan-strack-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/developing-conditional-mouse-models-and-new-approaches-to-treating-arsacs-dr-stefan-strack-2\/","title":{"rendered":"Developing conditional mouse models and new approaches to treating ARSACS \u2013 Dr Strack"},"content":{"rendered":"<p>The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the Sacs KO model of ARSACS with a drug that raises levels of a second messenger (cAMP) in the brain and that is currently in phase 2 and phase 3 clinical trials for two neurodevelopmental disorders. Second, we propose to develop gene therapy for ARSACS. Third, we have generated a conditional Sacs KO model, which we will use to pinpoint where and when Sacs loss-of-function causes the spectrum of ARSACS symptoms.<\/p>\r\n<p class=\"m_-2151711370727717155MsoListParagraph\">Subvention : 100 000$<\/p>\r\n<p><strong>Il s'agit d'un projet financ\u00e9 conjointement avec l' Action for ARSACS  Foundation USA  (AFA)<\/strong><\/p>\r\n<p>Dur\u00e9e : un an\u00a0<\/p>\r\n<p>&nbsp;<\/p>\r\n\r\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns: 22% auto;\">\r\n<figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"180\" class=\"wp-image-19044 size-full\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2023\/09\/Strack.jpg\" alt=\"\" \/><\/figure>\r\n<div class=\"wp-block-media-text__content\">\r\n<p class=\"wp-block-paragraph\">Dr Stefan Strack<br \/>D\u00e9partement de neurosciences et de pharmacologie<br \/>Facult\u00e9 de m\u00e9decine Carver de l'Universit\u00e9 de l'Iowa<br \/>2-452 BSB, 51, Newton Road.<br \/>Iowa City, IA 52242, \u00c9tats-Unis<\/p>\r\n\r\n\r\n\r\n<p class=\"wp-block-paragraph\">Coordonn\u00e9es :<a href=\"mailto:Stefan-strack@uiowa.edu\">Stefan-strack@uiowa.edu<\/a><\/p>\r\n<\/div>\r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>The Sacs knock-out (KO) mouse is a faithful model of ARSACS, displaying ataxia, muscle weakness, cerebellar degeneration, and, as we have recently shown, learning and memory deficits. With this proposal, we seek to pharmacologically rescue motor- and cognitive phenotypes in the Sacs KO model of ARSACS with a drug that raises levels of a second [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-22700","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=22700"}],"version-history":[{"count":8,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22700\/revisions"}],"predecessor-version":[{"id":27012,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/22700\/revisions\/27012"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=22700"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=22700"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=22700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}