{"id":22716,"date":"2025-09-25T14:28:57","date_gmt":"2025-09-25T18:28:57","guid":{"rendered":"https:\/\/www.arsacs.com\/?p=22716"},"modified":"2025-09-25T14:28:57","modified_gmt":"2025-09-25T18:28:57","slug":"exploring-the-role-of-sacsin-on-blood-brain-barrier-cell-structure-behavior-and-function-dr-federico-herrera","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/exploring-the-role-of-sacsin-on-blood-brain-barrier-cell-structure-behavior-and-function-dr-federico-herrera\/","title":{"rendered":"&#8220;Exploring the Role of Sacsin on Blood-Brain Barrier Cell Structure, Behavior and Function&#8221; &#8211; Dr Federico Herrera"},"content":{"rendered":"\n<p><\/p>\n\n\n<p class=\"x_MsoNormal\"><span data-olk-copy-source=\"MessageBody\">Loss of sacsin affect neurons in the cerebellum, but the role of other, non-neuronal brain cells in ARSACS has been less studied. The team discovered high amounts of sacsin in the cells that form the blood-brain barrier\u2014a protective layer that keeps harmful substances in the bloodstream out of the brain. They plan to remove sacsin from these cells in the lab to see if it makes the barrier leakier and more fragile. If true, these findings could reveal new ways that ARSACS harms the brain and point to possible new treatments.<\/span><\/p>\n<p>Financement: 25 000$<\/p>\n<p>Dur\u00e9e : un an<\/p>\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:29% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"924\" height=\"924\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/01\/Federico_Herrera.jpeg\" alt=\"\" class=\"wp-image-19673 size-full\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/01\/Federico_Herrera.jpeg 924w, https:\/\/arsacs.com\/wp-content\/uploads\/2024\/01\/Federico_Herrera-480x480.jpeg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 924px, 100vw\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>Dr Federico Herrera<br>Cell Structure and Dynamics Laboratory<br>Department of Chemistry and Biochemistry (DQB)<br>Faculty of Sciences, University of Lisbon<br>Edif\u00edcio C8, Campo Grande<br>1749-016 Lisboa<br>Portugal<\/p>\n\n\n\n<p>Coordonn\u00e9es:\u00a0\u00a0<a href=\"mailto:fherrera@fc.ul.pt\">fherrera@fc.ul.pt<\/a><\/p>\n\n\n\n<p><\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Loss of sacsin affect neurons in the cerebellum, but the role of other, non-neuronal brain cells in ARSACS has been less studied. The team discovered high amounts of sacsin in the cells that form the blood-brain barrier\u2014a protective layer that keeps harmful substances in the bloodstream out of the brain. They plan to remove sacsin [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-22716","post","type-post","status-publish","format-standard","hentry","category-projets-de-recherche"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>&quot;Exploring the Role of Sacsin on Blood-Brain Barrier Cell Structure, Behavior and Function&quot; - Dr Federico Herrera - ARSACS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/arsacs.com\/fr\/exploring-the-role-of-sacsin-on-blood-brain-barrier-cell-structure-behavior-and-function-dr-federico-herrera\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;Exploring the Role of Sacsin on Blood-Brain Barrier Cell Structure, Behavior and Function&quot; - Dr Federico Herrera - ARSACS\" \/>\n<meta property=\"og:description\" content=\"Loss of sacsin affect neurons in the cerebellum, but the role of other, non-neuronal brain cells in ARSACS has been less studied. The team discovered high amounts of sacsin in the cells that form the blood-brain barrier\u2014a protective layer that keeps harmful substances in the bloodstream out of the brain. 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