{"id":26501,"date":"2025-10-22T11:42:37","date_gmt":"2025-10-22T15:42:37","guid":{"rendered":"https:\/\/2026.arsacs.com\/?p=26501"},"modified":"2026-06-25T11:46:56","modified_gmt":"2026-06-25T15:46:56","slug":"modelling-arsacs-in-human-in-ipsc-derived-cerebellar-organoids-dr-esther-becker-2","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/modelling-arsacs-in-human-in-ipsc-derived-cerebellar-organoids-dr-esther-becker-2\/","title":{"rendered":"\u201c Mod\u00e9lisation de l\u2019ARSACS chez l\u2019homme \u00e0 l\u2019aide d\u2019organo\u00efdes c\u00e9r\u00e9belleux d\u00e9riv\u00e9s de cellules iPS \u201d \u2013 Dr Esther Becker"},"content":{"rendered":"<p class=\"wp-block-paragraph\">This project aims to create three-dimensional disease models called \u2018organoids\u2019 using induced pluripotent stem cells (iPSCs) from ARSACS patients. Human iPSCs are obtained from individuals\u2019 skin cells by a process known as reprogramming and resemble stem cells present in the developing human embryo that are capable of turning into any cell type in the body. Coaxing these iPSCs into brain cells allows us to study living human nerve cells from affected patients in the laboratory and to recapitulate early events that lead to disease. This innovative method will allow us to better understand why it is the Purkinje cells in the cerebellum that are particularly affected in ARSACS. We propose to produce cerebellar organoids from ARSACS iPSCs and compare these to organoids generated from healthy controls. This will shed light on the molecular and cellular processes that go awry in the ARSACS cerebellum and that might be amenable to therapeutic correction. In the long term, we hope that cerebellar organoid models for ARSACS will help to develop better treatments for this disease.<\/p>\n<p class=\"wp-block-paragraph\">Grant: $76,772<\/p>\n<p class=\"wp-block-paragraph\">Duration: second year of a 2 year project<\/p>\n<div class=\"wp-block-media-text is-stacked-on-mobile\">\n<figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-24043 size-full alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2026\/03\/Dr.-Esther-Becker.jpg\" alt=\"\" width=\"300\" height=\"246\" \/><\/figure>\n<div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\">University of Oxford<br \/>\nNuffield Department of Clinical Neurosciences<br \/>\nKavli Institute for Nanoscience Discovery<br \/>\nDorothy Crowfoot Hodgkin Building<br \/>\nOxford OX1 3QU<br \/>\nUnited Kingdom<br \/>\nContact :\u00a0<a href=\"mailto:esther.becker@ndcn.ox.ac.uk\">esther.becker@ndcn.ox.ac.uk<\/a><\/p>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This project aims to create three-dimensional disease models called \u2018organoids\u2019 using induced pluripotent stem cells (iPSCs) from ARSACS patients. Human iPSCs are obtained from individuals\u2019 skin cells by a process known as reprogramming and resemble stem cells present in the developing human embryo that are capable of turning into any cell type in the body. [&#8230;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34,94],"tags":[],"class_list":["post-26501","post","type-post","status-publish","format-standard","hentry","category-current","category-research-projects-2025-2026"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26501"}],"version-history":[{"count":1,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26501\/revisions"}],"predecessor-version":[{"id":26502,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26501\/revisions\/26502"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}