{"id":26853,"date":"2026-09-02T17:13:40","date_gmt":"2026-09-02T21:13:40","guid":{"rendered":"https:\/\/arsacs.com\/?p=26853"},"modified":"2026-09-02T17:24:21","modified_gmt":"2026-09-02T21:24:21","slug":"unveiling-the-role-of-microglia-in-arsacs","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/unveiling-the-role-of-microglia-in-arsacs\/","title":{"rendered":"Unveiling the Role of Microglia in ARSACS"},"content":{"rendered":"<p>ARSACS research has traditionally focused on neurons, particularly Purkinje cells in the cerebellum. However, growing evidence suggests that microglia, the immune cells of the brain, may also contribute to the disease. Recent findings indicate that abnormal microglial activity may appear very early in ARSACS, even before significant neuronal loss occurs. This project will investigate whether microglia are simply reacting to neuronal damage or actively contributing to disease progression. Researchers will combine two complementary models: microglial cells and neurons generated from stem cells derived from ARSACS patients, and a genetically modified zebrafish model that allows microglia and neurons to be observed in the living brain. The team will study inflammation, metabolism and cell interactions, and will also test therapeutic approaches designed to reduce harmful inflammation and protect neurons. The findings could reveal new mechanisms and therapeutic targets for ARSACS.<\/p>\n<p>Subvention : $100 000<br data-start=\"409\" data-end=\"412\" \/>Duration: One year<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-22637 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2025\/09\/PORTRAIT_Damiani-240x300.jpg\" alt=\"\" width=\"240\" height=\"300\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2025\/09\/PORTRAIT_Damiani-240x300.jpg 240w, https:\/\/arsacs.com\/wp-content\/uploads\/2025\/09\/PORTRAIT_Damiani-819x1024.jpg 819w, https:\/\/arsacs.com\/wp-content\/uploads\/2025\/09\/PORTRAIT_Damiani-768x960.jpg 768w, https:\/\/arsacs.com\/wp-content\/uploads\/2025\/09\/PORTRAIT_Damiani-scaled.jpg 924w, https:\/\/arsacs.com\/wp-content\/uploads\/2025\/09\/PORTRAIT_Damiani-480x600.jpg 480w\" sizes=\"(max-width: 240px) 100vw, 240px\" \/><strong data-start=\"458\" data-end=\"479\">Dr. Devid Damiani<\/strong><br data-start=\"479\" data-end=\"482\" \/>Via dei Giacinti 2, 56128<br data-start=\"507\" data-end=\"510\" \/>Calambrone (PI), Italy<br data-start=\"532\" data-end=\"535\" \/>Contact : <strong data-start=\"544\" data-end=\"571\"><a class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-start=\"546\" data-end=\"569\">devid.damiani@gmail.com<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>This project investigates whether microglia, the immune cells of the brain, contribute directly to ARSACS progression and explores strategies to reduce harmful inflammation and protect neurons.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[104],"tags":[],"class_list":["post-26853","post","type-post","status-publish","format-standard","hentry","category-research-projects-2026-2027"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26853"}],"version-history":[{"count":7,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26853\/revisions"}],"predecessor-version":[{"id":26864,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26853\/revisions\/26864"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}