{"id":26869,"date":"2026-09-11T09:34:44","date_gmt":"2026-09-11T13:34:44","guid":{"rendered":"https:\/\/arsacs.com\/?p=26869"},"modified":"2026-09-11T09:36:11","modified_gmt":"2026-09-11T13:36:11","slug":"identification-des-modificateurs-genetiques-susceptibles-dinfluencer-les-symptomes-de-larsac-dr-girard","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/identifying-genetic-modifiers-that-may-influence-arsacs-symptoms-dr-girard\/","title":{"rendered":"Identifying Genetic Modifiers That May Influence ARSACS Symptoms \u2013 Dr Girard"},"content":{"rendered":"<p>A variability of symptoms exist among ARSACS patients which suggests that modifier genes might be implicated even among patients from the SLSJ region, and genetic variations rarely act alone. The team has already used genotyping and genealogical data to confirm a founder haplotype Hypothesis: modifier genes, beyond the known SACS variant, are also shared among patients. Hypothesis: modifiers may not strictly follow the same path observed for the primary ARSACS variant but may instead segregate within subsets of related individuals. They will now use regions of IBD instead of SNPs from GWAS to find causal associations with ARSACS.<\/p>\n<p>Subvention : $98,314<br \/>\n<strong>Ce projet est cofinanc\u00e9 avec le Richardson Trust Fund  - une contribution de  50 000$.<\/strong><br data-start=\"847\" data-end=\"850\" \/>Dur\u00e9e : un an<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-19244 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2023\/10\/Simon-Girard--225x300.jpg\" alt=\"\" width=\"225\" height=\"300\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2023\/10\/Simon-Girard--225x300.jpg 225w, https:\/\/arsacs.com\/wp-content\/uploads\/2023\/10\/Simon-Girard-.jpg 300w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><strong data-start=\"929\" data-end=\"948\">Dr Simon Girard<\/strong><br data-start=\"948\" data-end=\"951\" \/>Professeur<br data-start=\"960\" data-end=\"963\" \/>Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi<br data-start=\"996\" data-end=\"999\" \/>555, boulevard de l'Universit\u00e9<br data-start=\"1019\" data-end=\"1022\" \/>Chicoutimi, Qu\u00e9bec G7H 2G1<br data-start=\"1048\" data-end=\"1051\" \/>Contact : <strong data-start=\"1060\" data-end=\"1085\"><a class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-start=\"1062\" data-end=\"1083\">simon2_girard@uqac.ca<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>This project investigates genetic modifiers that may help explain differences in symptoms among people living with ARSACS.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-26869","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26869"}],"version-history":[{"count":8,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26869\/revisions"}],"predecessor-version":[{"id":26992,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26869\/revisions\/26992"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}