{"id":26872,"date":"2026-09-11T08:33:20","date_gmt":"2026-09-11T12:33:20","guid":{"rendered":"https:\/\/arsacs.com\/?p=26872"},"modified":"2026-09-11T08:33:20","modified_gmt":"2026-09-11T12:33:20","slug":"exploring-oligodendrocyte-dysfunction-and-s100b-signaling-in-arsacs-dr-herrera","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/exploring-oligodendrocyte-dysfunction-and-s100b-signaling-in-arsacs-dr-herrera\/","title":{"rendered":"\u00c9tude du dysfonctionnement des oligodendrocytes et de la voie de signalisation S100B dans le syndrome d'ARSACS \u2013 Dr Herrera"},"content":{"rendered":"<p>This proposal investigates the role of oligodendrocyte dysfunction and S100B signaling in ARSACS. The central hypothesis is that sacsin deficiency alters oligodendrocyte differentiation and function through dysregulation of S100B, a calcium-binding protein involved in myelination, neuroinflammation, cytoskeletal organization, and chaperone activity. The investigators propose to generate the first human oligodendrocyte model of ARSACS by directly reprogramming patient-derived fibroblasts into oligodendrocyte-like cells, characterize the effects of sacsin loss on oligodendrocyte biology, and determine whether manipulation of S100B expression or activity can rescue disease-associated phenotypes.<\/p>\n<p>Subvention : $25 000<br \/>\nDur\u00e9e : un an<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-19675 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2024\/01\/Federico_Herrera-300x300.jpeg\" alt=\"\" width=\"300\" height=\"300\" \/><strong data-start=\"1137\" data-end=\"1160\">Dr. Federico Herrera<\/strong><br data-start=\"1160\" data-end=\"1163\" \/>Laboratory Head<br data-start=\"1178\" data-end=\"1181\" \/>Cell Structure and Dynamics Laboratory<br data-start=\"1219\" data-end=\"1222\" \/>Faculty of Sciences, University of Lisbon<br data-start=\"1263\" data-end=\"1266\" \/>Lisbonne, Portugal<br data-start=\"1282\" data-end=\"1285\" \/>Contact : <strong data-start=\"1294\" data-end=\"1315\"><a class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-start=\"1296\" data-end=\"1313\">fherrera@fc.ul.pt<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Ce projet \u00e9tudie le r\u00f4le du dysfonctionnement des oligodendrocytes et de la voie de signalisation S100B dans l'ARSACS.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-26872","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26872"}],"version-history":[{"count":7,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26872\/revisions"}],"predecessor-version":[{"id":26963,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26872\/revisions\/26963"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}