{"id":26878,"date":"2026-09-11T08:14:13","date_gmt":"2026-09-11T12:14:13","guid":{"rendered":"https:\/\/arsacs.com\/?p=26878"},"modified":"2026-09-11T08:14:13","modified_gmt":"2026-09-11T12:14:13","slug":"restauration-de-lactivite-des-cellules-de-purkinje-par-la-modulation-des-canaux-ioniques-et-du-gene-mglur1-dr-mckinney","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/restoring-purkinje-cell-activity-through-ion-channel-and-mglur1-modulation-dr-mckinney\/","title":{"rendered":"Restoring Purkinje Cell Activity Through Ion Channel and mGluR1 Modulation \u2013 Dre McKinney"},"content":{"rendered":"<p>The McKinney lab is requesting 1 year of funding to (1) finalize their exciting data showing that modulating a downregulated sodium channel subunit could correct Purkinje cell firing and ataxia; and (2) to advance their preliminary data showing a down regulation of mGluR1 and to test if modulating mGluR1 can rescue or slow down the ataxia.<\/p>\n<p>Subvention : $99 000<br data-start=\"667\" data-end=\"670\" \/>Dur\u00e9e : un an<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-10760 alignleft\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Anne-McKinney-235x300.jpg\" alt=\"\" width=\"235\" height=\"300\" \/><strong data-start=\"764\" data-end=\"784\">Dr Anne McKinney<\/strong><br data-start=\"784\" data-end=\"787\" \/>Professeur<br data-start=\"796\" data-end=\"799\" \/>D\u00e9partement de pharmacologie et de th\u00e9rapeutique<br data-start=\"842\" data-end=\"845\" \/>Universit\u00e9 McGill<br data-start=\"862\" data-end=\"865\" \/>Complexe des sciences de la vie, Bellini, salle 167<br data-start=\"905\" data-end=\"908\" \/>3649, avenue Sir-William-Osler<br data-start=\"936\" data-end=\"939\" \/>Montr\u00e9al, Qu\u00e9bec H3G 0B1<br data-start=\"963\" data-end=\"966\" \/>Contact : <strong data-start=\"975\" data-end=\"1002\"><a class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-start=\"977\" data-end=\"1000\">anne.mckinney@mcgill.ca<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>This project investigates whether modulation of a sodium channel subunit and mGluR1 can restore Purkinje cell function and slow ataxia in ARSACS.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-26878","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26878"}],"version-history":[{"count":5,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26878\/revisions"}],"predecessor-version":[{"id":26967,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26878\/revisions\/26967"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}