{"id":26881,"date":"2026-09-11T08:02:57","date_gmt":"2026-09-11T12:02:57","guid":{"rendered":"https:\/\/arsacs.com\/?p=26881"},"modified":"2026-09-14T12:37:07","modified_gmt":"2026-09-14T16:37:07","slug":"etude-des-alterations-du-cytosquelette-nucleaire-chez-les-patients-atteints-darsac-dr-morani","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/investigating-nuclear-cytoskeletal-alterations-in-arsacs-dr-morani\/","title":{"rendered":"Investigating Nuclear\u2013Cytoskeletal Alterations in ARSACS \u2013 Dre Morani et Dr Carollo"},"content":{"rendered":"

The applicant proposes to investigate the potential crosstalk between sacsin loss of function and disruption of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex as a mechanobiological contributor to ARSACS pathogenesis.<\/p>\n

The rationale is based on sacsin\u2019s known role as a molecular chaperone involved in cytoskeletal organization and prior observations from the lab on nuclear envelope changes in sacsin-deficient cells. The applicant hypothesizes that sacsin deficiency may impair LINC complex function, contributing to disease mechanisms through altered nuclear-cytoskeletal interactions.<\/p>\n

Subvention : $100 000
\nCe projet est cofinanc\u00e9 avec Richardson Trust Fund - une contribution de 45 000$.<\/strong>
Dur\u00e9e : un an<\/p>\n

\"\"\"\"Dre Federica Morani et Dr Pietro Salvatore Carollo<\/strong>
\nD\u00e9partement de m\u00e9decine et de chirurgie
\n\u201cL'universit\u00e9 \u201d Kore \u00bb d'Enna (UKE),
\nB\u00e2timent des sciences de la vie et de la technologie
\nContrada Santa Panasia, 94100 Enna, Italie<\/p>\n

Contacts :
\nfederica.morani@unikore.it\u00a0<\/a>
\npietro.carollo@unikore.it<\/a><\/p>","protected":false},"excerpt":{"rendered":"

This project investigates how disruption of nuclear\u2013cytoskeletal interactions and the LINC complex may contribute to ARSACS pathogenesis.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-26881","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26881"}],"version-history":[{"count":10,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26881\/revisions"}],"predecessor-version":[{"id":27030,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26881\/revisions\/27030"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}