{"id":26881,"date":"2026-09-11T08:02:57","date_gmt":"2026-09-11T12:02:57","guid":{"rendered":"https:\/\/arsacs.com\/?p=26881"},"modified":"2026-09-11T08:02:57","modified_gmt":"2026-09-11T12:02:57","slug":"investigating-nuclear-cytoskeletal-alterations-in-arsacs-dr-morani","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/investigating-nuclear-cytoskeletal-alterations-in-arsacs-dr-morani\/","title":{"rendered":"\u00c9tude des alt\u00e9rations du cytosquelette nucl\u00e9aire dans l'ARSACS \u2013 Dr Morani"},"content":{"rendered":"<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"277\" data-end=\"510\">The applicant proposes to investigate the potential crosstalk between sacsin loss of function and disruption of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex as a mechanobiological contributor to ARSACS pathogenesis.<\/p>\n<p data-start=\"517\" data-end=\"924\">The rationale is based on sacsin\u2019s known role as a molecular chaperone involved in cytoskeletal organization and prior observations from the lab on nuclear envelope changes in sacsin-deficient cells. The applicant hypothesizes that sacsin deficiency may impair LINC complex function, contributing to disease mechanisms through altered nuclear-cytoskeletal interactions.<\/p>\n<p data-start=\"517\" data-end=\"924\">Subvention : $100 000<br \/>\n<strong>This project is jointly funded with the Richardson Trust Fund, contributing $45,000<\/strong><br data-start=\"953\" data-end=\"956\" \/>Dur\u00e9e : un an<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-10937 size-full\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Morani_Federica-225x300-2.jpg\" alt=\"Dr Federica Morani\" width=\"225\" height=\"300\" srcset=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Morani_Federica-225x300-2.jpg 225w, https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/Morani_Federica-225x300-2-150x200.jpg 150w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><strong data-start=\"1047\" data-end=\"1069\">Dr. Federica Morani<\/strong><br data-start=\"1069\" data-end=\"1072\" \/>The BioRobotics Institute<br data-start=\"1097\" data-end=\"1100\" \/>Scuola Superiore Sant\u2019Anna<br data-start=\"1126\" data-end=\"1129\" \/>Pisa, Italy<br data-start=\"1140\" data-end=\"1143\" \/>Contact : <strong data-start=\"1152\" data-end=\"1187\"><a class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-start=\"1154\" data-end=\"1185\">Federica.Morani@santannapisa.it<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Ce projet vise \u00e0 \u00e9tudier comment la perturbation des interactions entre le noyau et le cytosquelette, ainsi que celle du complexe LINC, pourrait contribuer \u00e0 la pathogen\u00e8se de l'ARSACS.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-26881","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26881"}],"version-history":[{"count":8,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26881\/revisions"}],"predecessor-version":[{"id":26990,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26881\/revisions\/26990"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}