{"id":26886,"date":"2026-09-11T08:04:36","date_gmt":"2026-09-11T12:04:36","guid":{"rendered":"https:\/\/arsacs.com\/?p=26886"},"modified":"2026-09-11T08:04:36","modified_gmt":"2026-09-11T12:04:36","slug":"understanding-early-synaptic-and-neuroinflammatory-changes-in-arsacs-dr-watt","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/understanding-early-synaptic-and-neuroinflammatory-changes-in-arsacs-dr-watt\/","title":{"rendered":"Comprendre les modifications synaptiques et neuroinflammatoires pr\u00e9coces dans l'ARSACS \u2013 Dr Watt"},"content":{"rendered":"<p>Alterations in Purkinje cell synaptic terminals in the CN are among the first changes observed in ARSACS mice. Given the prevalent hypothesis that presynaptic changes lead to eventual cell death of the parent cell, we believe that understanding this is likely to provide novel therapeutic targets to prevent Purkinje cell loss. Our current results point to the interplay of neuronal synapses and the pro inflammatory milieu of astrocytes and microglia as players in the CN dysfunction. By identifying early synaptic and neuroinflammatory mechanisms that drive Purkinje cell degeneration, this work may reveal novel disease-modifying therapeutic targets for ARSACS. Although still in relatively early preclinical stages, these studies could establish future translational strategies aimed at slowing neurodegeneration and preserving motor function in patients.<\/p>\n<p>Subvention : $100 000<br data-start=\"1105\" data-end=\"1108\" \/>Dur\u00e9e : un an<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-11138\" src=\"https:\/\/arsacs.com\/wp-content\/uploads\/2021\/02\/watt-1-150x150-2.jpg\" alt=\"\" width=\"281\" height=\"281\" \/><strong data-start=\"1200\" data-end=\"1218\">Dr. Alanna Watt<\/strong><br data-start=\"1218\" data-end=\"1221\" \/>Professor, Department of Biology<br data-start=\"1253\" data-end=\"1256\" \/>Dean, Faculty of Science<br data-start=\"1280\" data-end=\"1283\" \/>McGill University<br data-start=\"1300\" data-end=\"1303\" \/>Bellini Life Sciences Complex<br data-start=\"1332\" data-end=\"1335\" \/>3649 Sir William Osler<br data-start=\"1357\" data-end=\"1360\" \/>Montreal, Quebec H3G 0B1<br data-start=\"1384\" data-end=\"1387\" \/>Contact : <strong data-start=\"1396\" data-end=\"1421\"><a class=\"decorated-link cursor-pointer\" rel=\"noopener\" data-start=\"1398\" data-end=\"1419\">alanna.watt@mcgill.ca<\/a><\/strong><\/p>","protected":false},"excerpt":{"rendered":"<p>Ce projet porte sur l'\u00e9tude des modifications synaptiques et neuroinflammatoires pr\u00e9coces susceptibles de contribuer \u00e0 la d\u00e9g\u00e9n\u00e9rescence des cellules de Purkinje dans le cadre de l'ARSACS.<\/p>","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-26886","post","type-post","status-publish","format-standard","hentry","category-current"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=26886"}],"version-history":[{"count":7,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26886\/revisions"}],"predecessor-version":[{"id":26973,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/26886\/revisions\/26973"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=26886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=26886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=26886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}