{"id":27052,"date":"2026-09-22T10:32:48","date_gmt":"2026-09-22T14:32:48","guid":{"rendered":"https:\/\/arsacs.com\/?p=27052"},"modified":"2026-09-22T11:17:23","modified_gmt":"2026-09-22T15:17:23","slug":"une-nouvelle-avancee-dans-la-comprehension-de-la-sacsin","status":"publish","type":"post","link":"https:\/\/arsacs.com\/fr\/a-new-step-forward-in-understanding-sacsin\/","title":{"rendered":"Une nouvelle avanc\u00e9e dans la compr\u00e9hension du SACSIN"},"content":{"rendered":"<p dir=\"auto\" data-start=\"320\" data-end=\"694\">Une \u00e9quipe de chercheurs italiens a publi\u00e9 une nouvelle \u00e9tude sur <strong data-start=\"275\" data-end=\"285\">SACSIN<\/strong>, la prot\u00e9ine impliqu\u00e9e dans l'ARSACS.<\/p>\n<p dir=\"auto\" data-start=\"320\" data-end=\"694\">Pour la premi\u00e8re fois, les chercheurs ont d\u00e9montr\u00e9 que le <strong data-start=\"376\" data-end=\"417\">Le domaine HEPN de la prot\u00e9ine SACSIN est capable de se lier \u00e0 l'ARN<\/strong>, r\u00e9v\u00e9lant ainsi une fonction mol\u00e9culaire jusque-l\u00e0 inconnue de cette prot\u00e9ine. Ils ont \u00e9galement observ\u00e9 qu\u2019une mutation associ\u00e9e \u00e0 l\u2019ARSACS, <strong data-start=\"540\" data-end=\"550\">F4574C<\/strong>, r\u00e9duit cette activit\u00e9 de liaison \u00e0 l'ARN et modifie le comportement et la localisation du domaine HEPN au sein des cellules.<\/p>\n<p dir=\"auto\" data-start=\"696\" data-end=\"1069\">Ces r\u00e9sultats apportent un nouvel \u00e9clairage sur les m\u00e9canismes cellulaires susceptibles d'\u00eatre impliqu\u00e9s dans l'ARSACS et pourraient, \u00e0 terme, contribuer \u00e0 la mise au point de nouvelles approches th\u00e9rapeutiques. Les auteurs soulignent toutefois que des recherches suppl\u00e9mentaires sont n\u00e9cessaires pour confirmer ces observations \u00e0 l'aide de la prot\u00e9ine SACSIN compl\u00e8te, ainsi que de mod\u00e8les neuronaux et animaux.<\/p>\n<p dir=\"auto\" data-start=\"1071\" data-end=\"1277\">Cette \u00e9tude, intitul\u00e9e <strong data-start=\"1091\" data-end=\"1162\">\u00ab Le domaine HEPN isol\u00e9 de la prot\u00e9ine SACSIN pr\u00e9sente une activit\u00e9 de liaison \u00e0 l'ARN \u00bb,<\/strong> a \u00e9t\u00e9 accept\u00e9 pour publication dans <em data-start=\"1200\" data-end=\"1238\">Sciences de la vie cellulaires et mol\u00e9culaires<\/em>.<\/p>\n<p dir=\"auto\" data-start=\"1279\" data-end=\"1306\"><a href=\"https:\/\/doi.org\/10.1007\/s00018-026-06369-w\" target=\"_blank\" rel=\"noopener\"><strong data-start=\"1279\" data-end=\"1306\">Lisez l'article dans son int\u00e9gralit\u00e9<\/strong><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>A team of Italian researchers has published a new study on SACSIN, the protein involved in ARSACS. For the first time, the researchers have shown that the HEPN domain of SACSIN can bind to RNA, revealing a previously unknown molecular function of the protein. They also observed that an ARSACS-associated mutation, F4574C, reduces this RNA-binding [&#8230;]<\/p>\n","protected":false},"author":9,"featured_media":26280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-27052","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/27052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/comments?post=27052"}],"version-history":[{"count":11,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/27052\/revisions"}],"predecessor-version":[{"id":27065,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/posts\/27052\/revisions\/27065"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media\/26280"}],"wp:attachment":[{"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/media?parent=27052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/categories?post=27052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/arsacs.com\/fr\/wp-json\/wp\/v2\/tags?post=27052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}