Seeking a link between ARSACS and essential metals
ARSACS is one of approximately 40 known human diseases that involve protein misfolding. Apart from ARSACS all of these diseases have been linked to dysregulation of essential transition metal ions, but this has never been investigated for ARSACS. Our research will employ state-of-the-art synchrotron X-ray methods to establish whether or not metal dysregulation is involved in ARSACS. We hypothesize that essential transition metals are perturbed in ARSACS, and that this perturbation is relevant to the development of the disease.
Grant : $65,000
This research project is funded jointly with the Richardson Research Fund who contributed $50,000 in addition to the contribution from the Foundation.
Contact:
Dr. Graham George,College of Arts & Sciences,University of Saskatchewan
9 Campus Drive
Saskatoon, SK S7N 5A5
g.george@usask.ca>