The overall aim of this research is to identify the potential co-occurrence of genomic variants beyond mutations in the SACS gene and the epigenetic effects that might explain the different phenotype severity existing among ARSACS patients. Grant: $52,000 Duration : one year Contact: Dr. Daniele Galatolo Molecular Medicine for Neurodegenerative and Neuromuscular Diseases Unit IRCCS Stella Maris Foundation via dei Giacinti 2, 56128 Calambrone (Pisa) - Italy email : daniele.galatolo@fsm.unipi.it