“Identification of cellular mechanisms underlying TPS-100 rescue of motor function in ARSACS mice” – Dr. Alanna Watt and Dr. Anne McKinney.

The McKinney and Watt labs, which are located in close proximity in the Bellini Life Sciences Complex and who already share a mouse colony of ARSACS mice (Sacs-/-) will determine the physiological mode of action of TPS-100 a pharma and aminopyridines on Purkinje cell function, including synaptic input and output. They will work closely together, to elucidate the mechanism of action of TPS-100, which has been shown to rescue motor function in ARSACS mice (personal communication,B. Brais), or similar other therapeutic agents. This work will advance the goal of a therapeutic intervention for ARSACS. Duration: two years Grant: $140,000 per year Contacts: Dr. Alanna Watt, Department of Biology McGill University Bellini Life Sciences Bldg. 3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1 Office: Rm. 265 | Lab: Rm. 257 Tel: (514)-398-2806; Fax: (514)-398-5069; Email: alanna.watt@mcgill.ca Dr. Anne McKinney, Department of Pharmacology and Therapeutics, McGill University Bellini Life Sciences Bldg 3469 Sir William Osler, Montreal, Quebec Canada H3G 0B1 Tel: (514)-398-5685; Fax: (514)-398-2045; Email: anne.mckinney@mcgill.ca