Identification and functional analysis of the Sacsin interactome using the BioID assay”– Dr. Bernard Brais and Dr. Eric Shoubridge

Continue the investigation of sacsin partners using the BioID assay, using the full length sacsin as well as different sacsin mutants and to further characterize ARSACS fibroblast cytoskeletal disorganization as a cell-based model. Duration: one year Grant: $100,000 Contacts: Dr. Bernard Brais, co-director of the neuromuscular group of the Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4 Tel:(514)-398-3334; Email: bernard.brais@mcgill.ca Dr. Eric Shoubridge, Montreal Neurological Institute and Hospital 3801 University Street Montreal, Quebec, Canada H3A 2B4 Tel: (514)-398-1997; Email: eric.shoubridge@mcgill.ca