Investigating the Link Between Impaired Mitochondrial and Calcium Dysregulation in SACS/Purkinje Neurons – Dr. Francesca Maltecca

The research project has three specific objectives: to test the distribution of mitochondria in distal dendritic branches of Sacs primary PCs; to evaluate dysregulation of Ca2+ homeostasis in Sacs mice and finally to test the efficacy of targeted therapy in Sacs mice. Duration: Second year of a two year project Grant: $100,000 Contact: Dr. Francesca Maltecca, Phd, Neurogenomics Unit(4A2) San Raffaele Scientific Institute,Via Olgettina,58,20132 Milan, Italy Tel:39 022643.9116; 022643.4777; Email: francesca.maltecca@hsr.it