Unbiased Sacsin Client Identification and Genetic Intervention in a Mouse Model of ARSACS- Dr. Stephen Strack

This research project utilizes Sacs KO mice to answer two fundamental questions: 1) Can we leverage recent advances in quantitative proteomics to uncover early biomarkers and perhaps drivers of ARSACS pathology in the cerebellum? 2) Can genetic modulation of the mitochondrial fission/fusion equilibrium counteract cerebellar symptoms and PC degeneration? Results from this research are expected to advance our understanding of ARSACS disease mechanisms and point to avenues for therapeutic intervention. Duration: one year Grant: $50,000 Contact : Dr.Stefan Strack, Professor of Pharmacology University of Iowa Carver College of Medicine 2-452 BSB, 51 Newton Rd. Iowa City, IA 52242 Tel:(office/lab): (319)384-44[39/47]; Fax: (319) 335-8930 www.medicine.uiowa.edu/pharmacology/faculty/strack.html